Is There Excess Oxidative Stress and Damage in Eyes of Patients with Retinitis Pigmentosa?

Peter A. Campochiaro, Rupert W. Strauss, Lili Lu, Gulnar Hafiz, Yulia Wolfson, Syed M. Shah, Raafay Sophie, Tahreem A. Mir, Hendrik P. Scholl

Research output: Contribution to journalShort surveypeer-review

Abstract

Retinitis pigmentosa (RP) is a group of diseases in which a mutation in one of the large variety of genes causes death of rod photoreceptors. After rods die, cone photoreceptors gradually die resulting in constriction of visual fields and eventual blindness in many patients. Studies in animal models of RP have demonstrated that oxidative damage is a major contributor to cone cell death. In this study, we extended those findings to patients with RP, because compared to control patients, those with RP showed significant reduction in the reduced to oxidized glutathione (GSH/GSSG) ratio in aqueous humor and a significant increase in aqueous protein carbonyl content. In contrast, there was no significant decrease in the serum GSH/GSSG ratio or increase in carbonyl content of serum proteins. These data indicate that patients with RP have ocular oxidative stress and damage in the absence of manifestations of systemic oxidative stress and/or damage indicating that demonstrations of oxidative damage-induced cone cell death in animal models of RP may translate to human RP. These observations lead to the hypothesis that potent antioxidants will promote cone survival and function in patients with RP and that the aqueous GSH/GSSG ratio and carbonyl content on proteins may provide useful biomarkers.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalAntioxidants and Redox Signaling
Volume23
Issue number7
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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