Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma? A comparison with AMACR

Xiaojun Wu, Majd Zayzafoon, Xinzhi Zhang, Omar Hameed

Research output: Contribution to journalArticle

Abstract

Our aim was to compare the usefulness of fatty acid synthase (FASn) with that of α-methylacyl coenzyme-A racemase (AMACR) in the diagnosis of prostatic adenocarcinoma. The expression of these 2 markers was compared in a tissue microarray containing 62 foci of benign glands and 36 foci of prostatic adenocarcinoma. Similar to AMACR, there was significantly higher FASn expression in adenocarcinoma compared with that in benign glands. The optimal accuracy rate and area under curve (AUC) by receiver operating characteristic analysis for FASn were not significantly different from those for AMACR (accuracy, 80% vs 87%; AUC, 0.942 vs 0.956; P for both, > .05). Moreover, in cases with coexistent malignant and benign glands on the same core, FASn could selectively distinguish a proportion of cases (17/21 [81%]) similar to using AMACR. We conclude that FASn may aid in the diagnosis of prostatic adenocarcinoma, at least to supplement AMACR as another positive marker of carcinoma and potentially increase diagnostic accuracy.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume136
Issue number2
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

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Fatty Acid Synthases
Adenocarcinoma
Area Under Curve
Racemases and Epimerases
Coenzymes
ROC Curve
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma? A comparison with AMACR. / Wu, Xiaojun; Zayzafoon, Majd; Zhang, Xinzhi; Hameed, Omar.

In: American Journal of Clinical Pathology, Vol. 136, No. 2, 01.08.2011, p. 239-246.

Research output: Contribution to journalArticle

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