Is there a role for diet monotherapy in adult epilepsy?

Mackenzie C. Cervenka, Bobbie J. Henry-Barron, Eric H. Kossoff

Research output: Contribution to journalArticlepeer-review


Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalEpilepsy and Behavior Case Reports
StatePublished - 2017


  • Adult
  • Epilepsy
  • Ketogenic
  • Modified Atkins Diet
  • Monotherapy
  • Seizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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