TY - JOUR
T1 - Is there a role for diet monotherapy in adult epilepsy?
AU - Cervenka, Mackenzie C.
AU - Henry-Barron, Bobbie J.
AU - Kossoff, Eric H.
N1 - Funding Information:
Mackenzie C. Cervenka, MD disclosure: The author has received support from The Epilepsy Foundation, The Johns Hopkins University School of Medicine Clinician Scientist Award, Nutricia, Vitaflo, Carson Harris Foundation, Owens Family Foundation, The BrightFocus Foundation, Elaine Freeman and Johns Hopkins University Department of Neurosurgery, Chris Garrod and Dawn Griffiths, Army Research Laboratory, and NIH (NINDS R01NS075020, NINDS 5U01NS053998).
Publisher Copyright:
© 2016 The Authors
PY - 2017
Y1 - 2017
N2 - Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended.
AB - Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended.
KW - Adult
KW - Epilepsy
KW - Ketogenic
KW - Modified Atkins Diet
KW - Monotherapy
KW - Seizure
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U2 - 10.1016/j.ebcr.2016.09.005
DO - 10.1016/j.ebcr.2016.09.005
M3 - Article
C2 - 28053859
AN - SCOPUS:85007242873
SN - 2213-3232
VL - 7
SP - 6
EP - 9
JO - Epilepsy and Behavior Case Reports
JF - Epilepsy and Behavior Case Reports
ER -