Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?

M. Alexander; A. Gupta; J. S. Mathad

doi:10.5588/ijtld.18.0337

Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?

M. Alexander, A. Gupta, J. S. Mathad

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. We review the epidemiology and immunology of GDM, and significant research gaps in understanding the interactions between GDM, pregnancy, and TB in women living with and those without HIV.

Original language	English (US)
Pages (from-to)	19-25
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	23
Issue number	1
DOIs	https://doi.org/10.5588/ijtld.18.0337
State	Published - Jan 1 2019

Keywords

DM
Immunology
Pregnancy
TB

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

Access to Document

10.5588/ijtld.18.0337

Cite this

@article{61419c87363041cc8690921b1d668450,

title = "Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?",

abstract = "Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. We review the epidemiology and immunology of GDM, and significant research gaps in understanding the interactions between GDM, pregnancy, and TB in women living with and those without HIV.",

keywords = "DM, Immunology, Pregnancy, TB",

author = "M. Alexander and A. Gupta and Mathad, {J. S.}",

note = "Funding Information: MA, AG, and JSM are supported by the Eunice Shriver National Institutes of Child Health and Development of the National Institutes of Health (NIH; Bethesda, MD, USA, R01HD081929) and by the Ujala Foundation (Newtown Square, PA, USA). JSM and AG are also supported by the National Institute of Allergy and Infectious Diseases of the NIH (K23AI129854 and UM1AI069465, respectively). AG receives support from the Gilead Foundation (Okehampton, UK) and Wyncote Foundation (Philadelphia, PA, USA). JSM receives support from the Kellen Foundation (New York, NY, USA). The content of the present study is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the other listed foundations. Conflicts of interest: none declared. Publisher Copyright: {\textcopyright} 2019 The Union.",

year = "2019",

month = jan,

day = "1",

doi = "10.5588/ijtld.18.0337",

language = "English (US)",

volume = "23",

pages = "19--25",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",