Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention- deficit/hyperactivity disorder? Analysis with brain-image database

Edward H. Herskovits, Vasileios Megalooikonomou, Christos Davatzikos, Anita Chen, R. Nick Bryan, Joan P. Gerring

Research output: Contribution to journalArticle

Abstract

PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD). MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-mage database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables. RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus. CONCLUSION: Closed-head injury-induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalRadiology
Volume213
Issue number2
StatePublished - Nov 1999

Fingerprint

Closed Head Injuries
Attention Deficit Disorder with Hyperactivity
Databases
Brain
Putamen
Software
Statistical Data Interpretation
Globus Pallidus
Caudate Nucleus
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • Attention-deficit/hyperactivity disorder
  • Brain, injuries
  • Brain, MR
  • Children, central nervous system
  • Images, analysis
  • Images, display

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention- deficit/hyperactivity disorder? Analysis with brain-image database. / Herskovits, Edward H.; Megalooikonomou, Vasileios; Davatzikos, Christos; Chen, Anita; Bryan, R. Nick; Gerring, Joan P.

In: Radiology, Vol. 213, No. 2, 11.1999, p. 389-394.

Research output: Contribution to journalArticle

Herskovits, Edward H. ; Megalooikonomou, Vasileios ; Davatzikos, Christos ; Chen, Anita ; Bryan, R. Nick ; Gerring, Joan P. / Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention- deficit/hyperactivity disorder? Analysis with brain-image database. In: Radiology. 1999 ; Vol. 213, No. 2. pp. 389-394.
@article{b52171046699431eb8cf9a770049653e,
title = "Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention- deficit/hyperactivity disorder? Analysis with brain-image database",
abstract = "PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD). MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-mage database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables. RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus. CONCLUSION: Closed-head injury-induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.",
keywords = "Attention-deficit/hyperactivity disorder, Brain, injuries, Brain, MR, Children, central nervous system, Images, analysis, Images, display",
author = "Herskovits, {Edward H.} and Vasileios Megalooikonomou and Christos Davatzikos and Anita Chen and Bryan, {R. Nick} and Gerring, {Joan P.}",
year = "1999",
month = "11",
language = "English (US)",
volume = "213",
pages = "389--394",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention- deficit/hyperactivity disorder? Analysis with brain-image database

AU - Herskovits, Edward H.

AU - Megalooikonomou, Vasileios

AU - Davatzikos, Christos

AU - Chen, Anita

AU - Bryan, R. Nick

AU - Gerring, Joan P.

PY - 1999/11

Y1 - 1999/11

N2 - PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD). MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-mage database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables. RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus. CONCLUSION: Closed-head injury-induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.

AB - PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD). MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-mage database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables. RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus. CONCLUSION: Closed-head injury-induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.

KW - Attention-deficit/hyperactivity disorder

KW - Brain, injuries

KW - Brain, MR

KW - Children, central nervous system

KW - Images, analysis

KW - Images, display

UR - http://www.scopus.com/inward/record.url?scp=0032754838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032754838&partnerID=8YFLogxK

M3 - Article

C2 - 10551217

AN - SCOPUS:0032754838

VL - 213

SP - 389

EP - 394

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -