Is the protection against ischemia induced by red wine linked to its antioxidant capacity?

Susana M. Mosca, Guillermo R. Schinella, Horacio A. Tournier, Horacio E. Cingolani

Research output: Contribution to journalArticle

Abstract

Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury. Animals and methods: The antioxidant properties of three RWE were determined using different free radical-generating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 μg/mL of RWE 1 (cabernet-sauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function. Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4%, 47±9% and 43±14% for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4% and 62±5%, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4% and 101±4% for RWE 1 and 92±5% and 91±5% for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction. Conclusion: These data show that although the three non-alcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalExperimental and Clinical Cardiology
Volume6
Issue number4
StatePublished - 2001
Externally publishedYes

Fingerprint

Wine
Ischemia
Antioxidants
Ventricular Pressure
Reperfusion
Myocardial Stunning
Blood Pressure
Reperfusion Injury
NADP
Superoxides

Keywords

  • Antioxidant capacity
  • Ischemia
  • Red wine
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mosca, S. M., Schinella, G. R., Tournier, H. A., & Cingolani, H. E. (2001). Is the protection against ischemia induced by red wine linked to its antioxidant capacity? Experimental and Clinical Cardiology, 6(4), 183-187.

Is the protection against ischemia induced by red wine linked to its antioxidant capacity? / Mosca, Susana M.; Schinella, Guillermo R.; Tournier, Horacio A.; Cingolani, Horacio E.

In: Experimental and Clinical Cardiology, Vol. 6, No. 4, 2001, p. 183-187.

Research output: Contribution to journalArticle

Mosca, SM, Schinella, GR, Tournier, HA & Cingolani, HE 2001, 'Is the protection against ischemia induced by red wine linked to its antioxidant capacity?', Experimental and Clinical Cardiology, vol. 6, no. 4, pp. 183-187.
Mosca, Susana M. ; Schinella, Guillermo R. ; Tournier, Horacio A. ; Cingolani, Horacio E. / Is the protection against ischemia induced by red wine linked to its antioxidant capacity?. In: Experimental and Clinical Cardiology. 2001 ; Vol. 6, No. 4. pp. 183-187.
@article{bd6b1614a29b4255a01a867981da9c0a,
title = "Is the protection against ischemia induced by red wine linked to its antioxidant capacity?",
abstract = "Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury. Animals and methods: The antioxidant properties of three RWE were determined using different free radical-generating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 μg/mL of RWE 1 (cabernet-sauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function. Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4{\%}, 47±9{\%} and 43±14{\%} for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4{\%} and 62±5{\%}, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4{\%} and 101±4{\%} for RWE 1 and 92±5{\%} and 91±5{\%} for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction. Conclusion: These data show that although the three non-alcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts.",
keywords = "Antioxidant capacity, Ischemia, Red wine, Reperfusion",
author = "Mosca, {Susana M.} and Schinella, {Guillermo R.} and Tournier, {Horacio A.} and Cingolani, {Horacio E.}",
year = "2001",
language = "English (US)",
volume = "6",
pages = "183--187",
journal = "Experimental and Clinical Cardiology",
issn = "1205-6626",
publisher = "Pulsus Group Inc.",
number = "4",

}

TY - JOUR

T1 - Is the protection against ischemia induced by red wine linked to its antioxidant capacity?

AU - Mosca, Susana M.

AU - Schinella, Guillermo R.

AU - Tournier, Horacio A.

AU - Cingolani, Horacio E.

PY - 2001

Y1 - 2001

N2 - Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury. Animals and methods: The antioxidant properties of three RWE were determined using different free radical-generating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 μg/mL of RWE 1 (cabernet-sauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function. Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4%, 47±9% and 43±14% for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4% and 62±5%, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4% and 101±4% for RWE 1 and 92±5% and 91±5% for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction. Conclusion: These data show that although the three non-alcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts.

AB - Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury. Animals and methods: The antioxidant properties of three RWE were determined using different free radical-generating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 μg/mL of RWE 1 (cabernet-sauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function. Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4%, 47±9% and 43±14% for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4% and 62±5%, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4% and 101±4% for RWE 1 and 92±5% and 91±5% for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction. Conclusion: These data show that although the three non-alcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts.

KW - Antioxidant capacity

KW - Ischemia

KW - Red wine

KW - Reperfusion

UR - http://www.scopus.com/inward/record.url?scp=0035710332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035710332&partnerID=8YFLogxK

M3 - Article

C2 - 20428256

AN - SCOPUS:0035710332

VL - 6

SP - 183

EP - 187

JO - Experimental and Clinical Cardiology

JF - Experimental and Clinical Cardiology

SN - 1205-6626

IS - 4

ER -