Is the mouse a good model of human PPARγ-related metabolic diseases?

Attila Pap, Ixchelt Cuaranta-Monroy, Matthew Peloquin, Laszlo Nagy

Research output: Contribution to journalReview article

Abstract

With the increasing number of patients affected with metabolic diseases such as type 2 diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and pharmaceutical companies are eager to better understand metabolic syndrome and develop new drugs for its treatment. Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect this transcription factor to several human metabolic diseases. Due to obvious limitations concerning experimentation in humans, animal models—mainly mouse models-have been generated to investigate the role of PPARγ in different tissues. This review focuses on the metabolic features of human and mouse PPARγ -related diseases and the utility of the mouse as a model.

Original languageEnglish (US)
Article number1236
JournalInternational Journal of Molecular Sciences
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

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Keywords

  • Human mutations
  • Ligand activation
  • Lipodystrophy
  • Metabolic syndrome
  • Mouse models
  • PPARγ expression

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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