Is the failing heart energy starved? On using chemical energy to support cardiac function

Joanne S. Ingwall, Robert G. Weiss

Research output: Contribution to journalReview article

Abstract

The requirement of chemical energy in the form of ATP to support systolic and diastolic work of the heart is absolute. Because of its central role in cardiac metabolism and performance, the subject of this review on energetics in the failing heart is ATP. We briefly review the basics of myocardial ATP metabolism and describe how this changes in the failing heart. We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalCirculation research
Volume95
Issue number2
DOIs
StatePublished - Jul 23 2004

Keywords

  • Adenosine triphosphate
  • Creatine kinase
  • Familial hypertrophic cardiomyopathy
  • Heart failure
  • Phosphocreatine

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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