Is the Carotid Body a Metabolic Monitor?

Research output: Contribution to journalArticle

Abstract

The carotid body is a multi-modal sensor and it has been debated if it senses low glucose. We have hypothesized that the carotid body is modified by some metabolic factors other than glucose and contributes to whole body glucose metabolism. This study examined the roles of insulin, leptin and transient receptor potential (TRP) channels on carotid sinus nerve (CSN) chemoreceptor discharge. In agreement with other studies, CSN activity was not modified by low glucose. Insulin did not affect the CSN hypoxic response. Leptin significantly augmented the CSN response to hypoxia and nonspecific Trp channel blockers (SKF96365, 2-APB) reversed the effect of leptin. Gene expression analysis showed high expression of Trpm3, 6, and 7 channels in the carotid body and petrosal ganglion. The results suggest that the adult mouse carotid body does not sense glucose levels directly. The carotid body may contribute to neural control of glucose metabolism via leptin receptor-mediated TRP channel activation.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume860
DOIs
StatePublished - 2015

Fingerprint

Carotid Body
Carotid Sinus
Glucose
Leptin
Transient Receptor Potential Channels
Leptin Receptors
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Metabolism
Insulin
Gene expression
Ganglia
Chemical activation
Gene Expression
Sensors

Keywords

  • CSN activity
  • Glucose
  • Insulin
  • Leptin
  • TRP channel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Is the Carotid Body a Metabolic Monitor? / Shirahata, M.; Tang, Wan-Yee; Shin, Mi-Kyung; Polotsky, Vsevolod.

In: Advances in Experimental Medicine and Biology, Vol. 860, 2015, p. 153-159.

Research output: Contribution to journalArticle

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