Is surgical excision necessary for atypical ductal hyperplasia of the breast diagnosed by Mammotome?

Gina Adrales, Peter Turk, Terry Wallace, Richard Bird, H. James Norton, Frederick Greene

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Core biopsy findings of atypical ductal hyperplasia (ADH) underestimates the diagnosis of malignancy by 18% to 88%. Using the Mammotome biopsy technique, more accurate assessment of the lesion is possible, making selective excision of these lesions a consideration. Methods: The records of 62 patients who were found to have ADH at Mammotome biopsy and subsequently underwent excision of the lesion were reviewed. Patient data were statistically analyzed for predictors of malignancy at the time of surgical excision. Results: Of the 62 patients, 9 (15%) had malignancy at excision. Variables predicting for malignancy included markedly atypical hyperplasia and incomplete removal of calcifications at Mammotome biopsy, a previous contralateral breast cancer, and a family history of breast cancer, with a combined sensitivity of 100% and specificity of 80%. Conclusions: Mild ADH found on Mammotome, not associated with a personal or family history of breast cancer, may not need excision if all calcifications have been removed. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish (US)
Pages (from-to)313-315
Number of pages3
JournalAmerican journal of surgery
Volume180
Issue number4
DOIs
StatePublished - Dec 18 2000
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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