TY - JOUR
T1 - Is protein folding hierarchic? II. Folding intermediates and transition states
AU - Baldwin, Robert L.
AU - Rose, George D.
N1 - Funding Information:
We thank our co-workers, past and present, for their discussions of these issues, and we apologize to our colleagues whose contributions could not be cited because of the limit on references. We thank the NIH for support (grant GM 19988 to R. L. B. and grant GM 29458 to G. D. R.).
PY - 1999/2/1
Y1 - 1999/2/1
N2 - The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the literature have been interpreted to the contrary. For these examples, we have simulated the local structures that form when folding begins by using the LINUS program with nonlocal interactions turned off. Our results support a hierarchic model of protein folding.
AB - The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the literature have been interpreted to the contrary. For these examples, we have simulated the local structures that form when folding begins by using the LINUS program with nonlocal interactions turned off. Our results support a hierarchic model of protein folding.
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U2 - 10.1016/S0968-0004(98)01345-0
DO - 10.1016/S0968-0004(98)01345-0
M3 - Review article
C2 - 10098403
AN - SCOPUS:0033080081
SN - 0968-0004
VL - 24
SP - 77
EP - 83
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 2
ER -