Is protein folding hierarchic? I. Local structure and peptide folding

Robert L. Baldwin, George D. Rose

Research output: Contribution to journalReview article


The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Nevertheless, we argue that both classes fold hierarchically and that folding begins locally. If this is the case, then the secondary structure of a protein is determined largely by local sequence information. Experimental data and theoretical considerations support this argument. Part I of this article reviews the relationship between secondary structures in proteins and their counterparts in peptides. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalTrends in biochemical sciences
Issue number1
StatePublished - Jan 1 1999


  • Biochemistry
  • Folding simulations
  • Hierarchic folding
  • Protein folding
  • Secondary-structure prediction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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