Is prostate cancer prevention with selenium all in the genes? Perspective on Penney et al., p. 604

Research output: Contribution to journalShort surveypeer-review

Abstract

This perspective discusses how well-conducted research by Penney et al. (beginning on page 604 in this issue of the journal) contributes to the incremental uncovering of the complex association between selenium and prostate cancer. These investigators' earlier findings and current questions, approaches, and findings regarding selenium for prostate cancer prevention are discussed. This group's work raises the following important inferences: Selenium may prevent poorer-prognosis prostate cancer and its progression to bony metastases and death, but only in men with genetic backgrounds that influence the requirement for selenium. These inferences point toward how to reconcile inconsistent prostate cancer risk results from the two randomized trials of selenium conducted to date.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalCancer Prevention Research
Volume3
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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