Is pain crisis a cause of death in sickle cell disease

N. A. Parfrey, G. W. Moore, G. M. Hutchins

    Research output: Contribution to journalArticle

    Abstract

    It has been a matter of controversy as to whether patients with sickle cell disease die of crisis or merely in crisis. The authors reviewed the 74 patients with sickle cell disease autopsied at The Johns Hopkins Hospital. From clinical review, there were 20 (27%) who died with pain crisis, 51 (69%) who died without pain crisis, and 3 (4%) for whom documentation was insufficient. On pathology review, death was attributable to infection in 19 (26%), uremia in 9 (12%), sequestration crisis in 9 (12%), necrotic bone marrow emboli in 7 (9%), and miscellaneous causes in 14 (19%); in 16 (22%) patients no cause of death could be identified. Death was explained in 47/51 (92%) patients without pain crisis; but only in 11/20 (55%, P

    Original languageEnglish (US)
    Pages (from-to)209-212
    Number of pages4
    JournalAmerican Journal of Clinical Pathology
    Volume84
    Issue number2
    StatePublished - 1985

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    Sickle Cell Anemia
    Cause of Death
    Pain
    Uremia
    Embolism
    Documentation
    Bone Marrow
    Pathology
    Infection

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

    Cite this

    Parfrey, N. A., Moore, G. W., & Hutchins, G. M. (1985). Is pain crisis a cause of death in sickle cell disease. American Journal of Clinical Pathology, 84(2), 209-212.

    Is pain crisis a cause of death in sickle cell disease. / Parfrey, N. A.; Moore, G. W.; Hutchins, G. M.

    In: American Journal of Clinical Pathology, Vol. 84, No. 2, 1985, p. 209-212.

    Research output: Contribution to journalArticle

    Parfrey, NA, Moore, GW & Hutchins, GM 1985, 'Is pain crisis a cause of death in sickle cell disease', American Journal of Clinical Pathology, vol. 84, no. 2, pp. 209-212.
    Parfrey, N. A. ; Moore, G. W. ; Hutchins, G. M. / Is pain crisis a cause of death in sickle cell disease. In: American Journal of Clinical Pathology. 1985 ; Vol. 84, No. 2. pp. 209-212.
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