During the last 20 yr, several claims have been made for the presence of large quantities of oestrogens in hops and it has been alleged that this hormonal activity appears in beer. The oestrogenic activities reported were very high in comparison with those in other plants. A number of purified hop components, including the essential-oil fraction and the α-and β-bitter acids obtained from hop resins, have now been examined and various organicsolvent extracts of hops grown in the USA and in Europe have been prepared and tested for oestrogenic activity, both directly and following saponification in base. Commercial hop extracts were also tested for oestrogenic activity. Wide ranges of dilutions of all preparations were examined by the uterine-weight assay in the immature female mouse. No oestrogenic activity was detectable in any of these preparations.
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