Is Na/Ca exchange during ischemia and reperfusion beneficial or detrimental?

Elizabeth Murphy, Heather R. Cross, Charles Steenbergen

Research output: Contribution to journalArticlepeer-review

Abstract

Cytosolic calcium increases to approximately 3 μM after 15 min of global ischemia. Manipulations that attenuate this increase in cytosolic Ca2+ reduce myocyte death and dysfunction. The increase in cytosolic Ca2+ during ischemia is dependent on an increase in intracellular Na+, suggesting a role for Na/Ca exchange. Typical ischemic values for ionized intra- and extracellular Na+, Ca2+, and membrane potential are consistent with the Na/Ca exchanger operating near equilibrium during ischemia. Studies were undertaken using hearts from mice that overexpress the Na/Ca exchanger to determine if Na/Ca exchanger overexpression enhances or reduces ischemic injury. These studies suggest that overexpression of the Na/Ca exchanger enhances injury in males, but females are protected by a gender-related mechanism.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume976
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Cytosolic calcium
  • Ischemia
  • Na/Ca exchanger

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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