Is lactate a volume transmitter of metabolic states of the brain?

Linda H. Bergersen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

We present the perspective that lactate is a volume transmitter of cellular signals in brain that acutely and chronically regulate the energy metabolism of large neuronal ensembles. From this perspective, we interpret recent evidence to mean that lactate transmission serves the maintenance of network metabolism by two different mechanisms, one by regulating the formation of cAMP via the lactate receptor GPR81, the other by adjusting the NADH/NAD+ redox ratios, both linked to the maintenance of brain energy turnover and possibly cerebral blood flow. The role of lactate as mediator of metabolic information rather than metabolic substrate answers a number of questions raised by the controversial oxidativeness of astrocytic metabolism and its contribution to neuronal function.

Original languageEnglish (US)
Article number5
JournalFrontiers in Neuroenergetics
Issue numberMAR
DOIs
StatePublished - 2012

Fingerprint

Lactic Acid
Brain
NAD
Cerebrovascular Circulation
Maintenance
Energy Metabolism
Oxidation-Reduction

Keywords

  • Central fatigue
  • Lactate
  • Lactate receptor
  • Metabolic information
  • Volume transmission

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Is lactate a volume transmitter of metabolic states of the brain? / Bergersen, Linda H.; Gjedde, Albert.

In: Frontiers in Neuroenergetics, No. MAR, 5, 2012.

Research output: Contribution to journalArticle

Bergersen, Linda H. ; Gjedde, Albert. / Is lactate a volume transmitter of metabolic states of the brain?. In: Frontiers in Neuroenergetics. 2012 ; No. MAR.
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