TY - JOUR
T1 - Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials?
AU - Kensler, Thomas W.
AU - Groopman, John D.
PY - 2009/12
Y1 - 2009/12
N2 - This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.
AB - This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.
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U2 - 10.1158/1940-6207.CAPR-09-0232
DO - 10.1158/1940-6207.CAPR-09-0232
M3 - Review article
C2 - 19952364
AN - SCOPUS:76549120583
SN - 1940-6207
VL - 2
SP - 1003
EP - 1007
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 12
ER -