Is impaired hepatic arterial buffer response a risk factor for biliary anastomotic stricture in liver transplant recipients?

Koji Hashimoto, Charles M. Miller, Cristiano Quintini, Federico N. Aucejo, Kenzo Hirose, Teresa Diago Uso, Loris Trenti, Dympna M. Kelly, Charles G. Winans, David P. Vogt, Bijan Eghtesad, John J. Fung

Research output: Contribution to journalArticle

Abstract

Background: Blood flow to the liver is partly maintained by the hepatic arterial buffer response (HABR), which is an intrinsic autoregulatory mechanism. Temporary clamping of the portal vein (PV) results in augmentation in hepatic artery flow (augHAF). Portal hyperperfusion impairs HAF due to the HABR in liver transplantation (LT). The aim of this study is to examine the effect of the HABR on biliary anastomotic stricture (BAS). Methods: In 234 cadaveric whole LTs, PV flow (PVF), basal HAF, and augHAF were measured intra-operatively after allograft implantation. All recipients with a vascular complication were excluded. Buffer capacity (BC) was calculated as (augHAF - basal HAF)/PVF to quantify the HABR. Recipients were divided into 2 groups based on their BC: low BC (<0.074; n = 117) or high BC (≥0.074; n = 117). Results: Of the 234 recipients, 23 (9.8%) had early BAS (≤60 days after LT) and 18 (7.7%) had late BAS (>60 days after LT). The incidence of late BAS and bile leakage was similar between the groups; however, the incidence of early BAS in the low BC group was greater than that in the high BC group (15% vs 5.1%; P = .0168). In the multivariate analysis, low BC (P = .0325) and bile leakage (P = .0002) were found to be independent risk factors affecting early BAS. Conclusion: Recipients with low BC who may have impaired HABR are at greater risk of early BAS after LT. Intraoperative measurements of blood flow help predict the risk of BAS.

Original languageEnglish (US)
Pages (from-to)582-588
Number of pages7
JournalSurgery
Volume148
Issue number3
DOIs
StatePublished - Sep 1 2010

ASJC Scopus subject areas

  • Surgery

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    Hashimoto, K., Miller, C. M., Quintini, C., Aucejo, F. N., Hirose, K., Uso, T. D., Trenti, L., Kelly, D. M., Winans, C. G., Vogt, D. P., Eghtesad, B., & Fung, J. J. (2010). Is impaired hepatic arterial buffer response a risk factor for biliary anastomotic stricture in liver transplant recipients? Surgery, 148(3), 582-588. https://doi.org/10.1016/j.surg.2010.01.019