Is human papillomavirus a primary factor in the causation of cervical neoplasia? Does herpes simplex virus play a subordinate role? Pro

Research output: Contribution to journalArticle

Abstract

It has been estimated that approximately 6 million women a year in the United States between the ages of 15 and 49 years are infected with HPV, yet there are only 15,000 incident cases of cervical cancer during this same period. The data demonstrating an inhibition of host cell control mediated by viral expression is consistent with the view that other events act synergistically with HPV to lead to malignant transformation. The nature of these other initiating events is not clear at present. It has been speculated that cigarette smoking, defects in cell-mediated immunity, and perhaps infection with HSV-2 may play a role in the cascade of events that lead from HPV infection of the cervix to invasive cancer.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalJournal of Gynecologic Surgery
Volume5
Issue number2
StatePublished - 1989

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Simplexvirus
Causality
Human Herpesvirus 2
Infection
Cervix Uteri
Cellular Immunity
Uterine Cervical Neoplasms
Neoplasms
Smoking
Inhibition (Psychology)

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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abstract = "It has been estimated that approximately 6 million women a year in the United States between the ages of 15 and 49 years are infected with HPV, yet there are only 15,000 incident cases of cervical cancer during this same period. The data demonstrating an inhibition of host cell control mediated by viral expression is consistent with the view that other events act synergistically with HPV to lead to malignant transformation. The nature of these other initiating events is not clear at present. It has been speculated that cigarette smoking, defects in cell-mediated immunity, and perhaps infection with HSV-2 may play a role in the cascade of events that lead from HPV infection of the cervix to invasive cancer.",
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