Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk

Chi Pang Wen, Ting Yuan David Cheng, Hui Ting Chan, Min Kuang Tsai, Wen Shen Isabella Chung, Shan Pou Tsai, Mark L. Wahlqvist, Yi Chen Yang, Shiuan Be Wu, Po Huang Chiang, Sung Feng Wen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cohort studies evaluating increased uric acid level as a cardiovascular disease (CVD) risk factor have shown variable results; studies are particularly lacking in lower risk populations. Study Design: Prospective cohort study. Setting & Participants: 484,568 adults participating in a medical screening program in Taiwan since 1994 were followed up for a median of 8.5 years. Two subgroups were constructed: the first (n = 246,697; 51%) excluded participants with either overt CVD or overt CVD risk factors (including hypertension, diabetes, obesity, and hypertriglyceridemia) and the second (n = 157,238; 32%) further excluded individuals with early-stage CVD risk factors (including prehypertension, prediabetes, overweight, and borderline hypertriglyceridemia). Predictor: Serum uric acid. Outcomes & Measurements: All-cause and CVD mortality risk assessed using Cox proportional hazards models for categorical and continuous serum uric acid levels. As applicable, models adjusted for 14 variables. Population-attributable fraction was applied to compare contributions to mortality between high uric acid level and other CVD risk factors. Results: In the total cohort, mean age was 41.4 ± 14.0 years and 26.2% had serum uric acid levels

Original languageEnglish (US)
Pages (from-to)273-288
Number of pages16
JournalAmerican Journal of Kidney Diseases
Volume56
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • cardiovascular disease
  • cohort
  • mortality
  • Serum uric acid

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

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