Abstract
Background: Cohort studies evaluating increased uric acid level as a cardiovascular disease (CVD) risk factor have shown variable results; studies are particularly lacking in lower risk populations. Study Design: Prospective cohort study. Setting & Participants: 484,568 adults participating in a medical screening program in Taiwan since 1994 were followed up for a median of 8.5 years. Two subgroups were constructed: the first (n = 246,697; 51%) excluded participants with either overt CVD or overt CVD risk factors (including hypertension, diabetes, obesity, and hypertriglyceridemia) and the second (n = 157,238; 32%) further excluded individuals with early-stage CVD risk factors (including prehypertension, prediabetes, overweight, and borderline hypertriglyceridemia). Predictor: Serum uric acid. Outcomes & Measurements: All-cause and CVD mortality risk assessed using Cox proportional hazards models for categorical and continuous serum uric acid levels. As applicable, models adjusted for 14 variables. Population-attributable fraction was applied to compare contributions to mortality between high uric acid level and other CVD risk factors. Results: In the total cohort, mean age was 41.4 ± 14.0 years and 26.2% had serum uric acid levels
Original language | English (US) |
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Pages (from-to) | 273-288 |
Number of pages | 16 |
Journal | American Journal of Kidney Diseases |
Volume | 56 |
Issue number | 2 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- cardiovascular disease
- cohort
- mortality
- Serum uric acid
ASJC Scopus subject areas
- Nephrology
- General Medicine