Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Gaya Spolverato, Yuhree Kim, Sorin Alexandrescu, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, T. Clark Gamblin, John Miura, Shishir K. Maithel, Malcolm H. Squires, Carlo Pulitano, Charbel Sandroussi, Gilles Mentha, Todd W. Bauer, Timothy Newhook, Feng Shen, George A. Poultsides, J. Wallis Marsh, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P  0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P 

Original languageEnglish (US)
Pages (from-to)2218-2225
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
Issue number7
DOIs
StatePublished - Oct 30 2014

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ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Spolverato, G., Kim, Y., Alexandrescu, S., Popescu, I., Marques, H. P., Aldrighetti, L., Clark Gamblin, T., Miura, J., Maithel, S. K., Squires, M. H., Pulitano, C., Sandroussi, C., Mentha, G., Bauer, T. W., Newhook, T., Shen, F., Poultsides, G. A., Wallis Marsh, J., & Pawlik, T. M. (2014). Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration. Annals of Surgical Oncology, 22(7), 2218-2225. https://doi.org/10.1245/s10434-014-4223-3