Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?

Nicola Scichilone, Fulvio Braido, Salvatore Taormina, Elena Pozzecco, Alessandra Paternò, Ilaria Baiardini, Vincenzo Casolaro, Giorgio Walter Canonica, Vincenzo Bellia

Research output: Contribution to journalArticle

Abstract

Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash. Results. The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: r=0.34, P=0.24; ECP: r=0.06, P=0.87) or bronchial inflammation (pH of the EBC: r=0.12, P=0.44; bronchial NO: r=0.27, P=0.22; alveolar NO: r=0.38, P=0.10). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT <20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (r=0.60, P=0.04). Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

Original languageEnglish (US)
Article number539290
JournalBioMed Research International
Volume2013
DOIs
StatePublished - 2013
Externally publishedYes

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Asthma
Quality of Life
Health
Inflammation
Rhinitis
Nose
Nitric Oxide
Eosinophils
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Scichilone, N., Braido, F., Taormina, S., Pozzecco, E., Paternò, A., Baiardini, I., ... Bellia, V. (2013). Is health-related quality of life associated with upper and lower airway inflammation in asthmatics? BioMed Research International, 2013, [539290]. https://doi.org/10.1155/2013/539290

Is health-related quality of life associated with upper and lower airway inflammation in asthmatics? / Scichilone, Nicola; Braido, Fulvio; Taormina, Salvatore; Pozzecco, Elena; Paternò, Alessandra; Baiardini, Ilaria; Casolaro, Vincenzo; Canonica, Giorgio Walter; Bellia, Vincenzo.

In: BioMed Research International, Vol. 2013, 539290, 2013.

Research output: Contribution to journalArticle

Scichilone, N, Braido, F, Taormina, S, Pozzecco, E, Paternò, A, Baiardini, I, Casolaro, V, Canonica, GW & Bellia, V 2013, 'Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?', BioMed Research International, vol. 2013, 539290. https://doi.org/10.1155/2013/539290
Scichilone, Nicola ; Braido, Fulvio ; Taormina, Salvatore ; Pozzecco, Elena ; Paternò, Alessandra ; Baiardini, Ilaria ; Casolaro, Vincenzo ; Canonica, Giorgio Walter ; Bellia, Vincenzo. / Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?. In: BioMed Research International. 2013 ; Vol. 2013.
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abstract = "Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash. Results. The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation ({\%} eosinophils: r=0.34, P=0.24; ECP: r=0.06, P=0.87) or bronchial inflammation (pH of the EBC: r=0.12, P=0.44; bronchial NO: r=0.27, P=0.22; alveolar NO: r=0.38, P=0.10). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT <20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (r=0.60, P=0.04). Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.",
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N2 - Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash. Results. The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: r=0.34, P=0.24; ECP: r=0.06, P=0.87) or bronchial inflammation (pH of the EBC: r=0.12, P=0.44; bronchial NO: r=0.27, P=0.22; alveolar NO: r=0.38, P=0.10). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT <20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (r=0.60, P=0.04). Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

AB - Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash. Results. The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: r=0.34, P=0.24; ECP: r=0.06, P=0.87) or bronchial inflammation (pH of the EBC: r=0.12, P=0.44; bronchial NO: r=0.27, P=0.22; alveolar NO: r=0.38, P=0.10). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT <20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (r=0.60, P=0.04). Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

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