Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey

Vanessa Garcia-Larsen    , Rhonda Arthur, James F. Potts, Peter H. Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brozek, Joanna Makowska, Marek L. Kowalski, Trine Thilsing, Thomas Keil, Paolo M. Matricardi, Kjell Torén, Thibaut Van Zele, Claus Bachert, Barbara Rymarczyk, Christer Janson, Bertil Forsberg & 2 others Ewa Nizankowska-Mogilnicka, Peter G J Burney

Research output: Contribution to journalArticle

Abstract

Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA2LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8% reported having at least 1 asthma symptom (asthma score ≥1), whilst 19.5% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (β-coefficient -2.34; 95% confidence interval [CI] -4.09, -0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted β-coefficient 0.23; 95% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.

Original languageEnglish (US)
Article number3
JournalClinical and Translational Allergy
Volume7
Issue number1
DOIs
StatePublished - Jan 27 2017
Externally publishedYes

Fingerprint

Sinusitis
Vegetables
Fruit
Hypersensitivity
Asthma
Confidence Intervals
Surveys and Questionnaires
Anti-Allergic Agents
Anti-Inflammatory Agents
Antioxidants
Food

Keywords

  • Adults
  • Asthma
  • Chronic rhino-sinusitis
  • Europe
  • Fruits
  • GALEN
  • Meta-analysis
  • Vegetables

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey. / Garcia-Larsen    , Vanessa; Arthur, Rhonda; Potts, James F.; Howarth, Peter H.; Ahlström, Matti; Haahtela, Tari; Loureiro, Carlos; Bom, Ana Todo; Brozek, Grzegorz; Makowska, Joanna; Kowalski, Marek L.; Thilsing, Trine; Keil, Thomas; Matricardi, Paolo M.; Torén, Kjell; Van Zele, Thibaut; Bachert, Claus; Rymarczyk, Barbara; Janson, Christer; Forsberg, Bertil; Nizankowska-Mogilnicka, Ewa; Burney, Peter G J.

In: Clinical and Translational Allergy, Vol. 7, No. 1, 3, 27.01.2017.

Research output: Contribution to journalArticle

Garcia-Larsen    , V, Arthur, R, Potts, JF, Howarth, PH, Ahlström, M, Haahtela, T, Loureiro, C, Bom, AT, Brozek, G, Makowska, J, Kowalski, ML, Thilsing, T, Keil, T, Matricardi, PM, Torén, K, Van Zele, T, Bachert, C, Rymarczyk, B, Janson, C, Forsberg, B, Nizankowska-Mogilnicka, E & Burney, PGJ 2017, 'Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey', Clinical and Translational Allergy, vol. 7, no. 1, 3. https://doi.org/10.1186/s13601-016-0140-9
Garcia-Larsen    , Vanessa ; Arthur, Rhonda ; Potts, James F. ; Howarth, Peter H. ; Ahlström, Matti ; Haahtela, Tari ; Loureiro, Carlos ; Bom, Ana Todo ; Brozek, Grzegorz ; Makowska, Joanna ; Kowalski, Marek L. ; Thilsing, Trine ; Keil, Thomas ; Matricardi, Paolo M. ; Torén, Kjell ; Van Zele, Thibaut ; Bachert, Claus ; Rymarczyk, Barbara ; Janson, Christer ; Forsberg, Bertil ; Nizankowska-Mogilnicka, Ewa ; Burney, Peter G J. / Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey. In: Clinical and Translational Allergy. 2017 ; Vol. 7, No. 1.
@article{3e12d414a7644969a8e3149a23503e45,
title = "Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey",
abstract = "Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA2LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8{\%} reported having at least 1 asthma symptom (asthma score ≥1), whilst 19.5{\%} had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (β-coefficient -2.34; 95{\%} confidence interval [CI] -4.09, -0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95{\%} CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted β-coefficient 0.23; 95{\%} CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.",
keywords = "Adults, Asthma, Chronic rhino-sinusitis, Europe, Fruits, GALEN, Meta-analysis, Vegetables",
author = "{Garcia-Larsen    }, Vanessa and Rhonda Arthur and Potts, {James F.} and Howarth, {Peter H.} and Matti Ahlstr{\"o}m and Tari Haahtela and Carlos Loureiro and Bom, {Ana Todo} and Grzegorz Brozek and Joanna Makowska and Kowalski, {Marek L.} and Trine Thilsing and Thomas Keil and Matricardi, {Paolo M.} and Kjell Tor{\'e}n and {Van Zele}, Thibaut and Claus Bachert and Barbara Rymarczyk and Christer Janson and Bertil Forsberg and Ewa Nizankowska-Mogilnicka and Burney, {Peter G J}",
year = "2017",
month = "1",
day = "27",
doi = "10.1186/s13601-016-0140-9",
language = "English (US)",
volume = "7",
journal = "Clinical and Translational Allergy",
issn = "2045-7022",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey

AU - Garcia-Larsen    , Vanessa

AU - Arthur, Rhonda

AU - Potts, James F.

AU - Howarth, Peter H.

AU - Ahlström, Matti

AU - Haahtela, Tari

AU - Loureiro, Carlos

AU - Bom, Ana Todo

AU - Brozek, Grzegorz

AU - Makowska, Joanna

AU - Kowalski, Marek L.

AU - Thilsing, Trine

AU - Keil, Thomas

AU - Matricardi, Paolo M.

AU - Torén, Kjell

AU - Van Zele, Thibaut

AU - Bachert, Claus

AU - Rymarczyk, Barbara

AU - Janson, Christer

AU - Forsberg, Bertil

AU - Nizankowska-Mogilnicka, Ewa

AU - Burney, Peter G J

PY - 2017/1/27

Y1 - 2017/1/27

N2 - Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA2LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8% reported having at least 1 asthma symptom (asthma score ≥1), whilst 19.5% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (β-coefficient -2.34; 95% confidence interval [CI] -4.09, -0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted β-coefficient 0.23; 95% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.

AB - Background: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA2LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results: A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8% reported having at least 1 asthma symptom (asthma score ≥1), whilst 19.5% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (β-coefficient -2.34; 95% confidence interval [CI] -4.09, -0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted β-coefficient 0.23; 95% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance: There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.

KW - Adults

KW - Asthma

KW - Chronic rhino-sinusitis

KW - Europe

KW - Fruits

KW - GALEN

KW - Meta-analysis

KW - Vegetables

UR - http://www.scopus.com/inward/record.url?scp=85010951450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010951450&partnerID=8YFLogxK

U2 - 10.1186/s13601-016-0140-9

DO - 10.1186/s13601-016-0140-9

M3 - Article

VL - 7

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

IS - 1

M1 - 3

ER -