TY - JOUR
T1 - Is diabetic retinopathy an independent risk factor for ischemic stroke?
AU - Cheung, Ning
AU - Rogers, Sophie
AU - Couper, David J.
AU - Klein, Ronald
AU - Sharrett, A. Richey
AU - Wong, Tien Y.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - BACKGROUND AND PURPOSE - The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS - A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS - Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS - Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
AB - BACKGROUND AND PURPOSE - The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS - A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS - Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS - Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
KW - Diabetic retinopathy
KW - Ischemic stroke
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U2 - 10.1161/01.STR.0000254547.91276.50
DO - 10.1161/01.STR.0000254547.91276.50
M3 - Article
C2 - 17194880
AN - SCOPUS:33846626856
SN - 0039-2499
VL - 38
SP - 398
EP - 401
JO - Stroke
JF - Stroke
IS - 2
ER -