Is adenovirus a fetal pathogen?

Ahmet Baschat, Jeffrey Towbin, Neil E. Bowles, Christopher R. Harman, Carl P. Weiner

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The purpose of this study was to test the relationship between adenovirus genetic material in the amniotic fluid and adverse pregnancy outcome. STUDY DESIGN: This was a prospective, observational study of women who were referred in the second trimester of gestation for either genetic amniocentesis or evaluation of fetal malformation. A 2-mL aliquot of amniotic fluid was subjected to multiplex polymerase chain reaction for a panel of viruses that included adenovirus and human genome controls. Fetuses with an abnormal karyotype were excluded from analysis. RESULTS: The prevalence of adenovirus was similar in normal (39/652) and anomalous fetuses (23/364; χ2 test, P = .376). There was significant seasonal variation in the prevalence in both normal and anomalous fetuses (χ2 exact test, P2 test, P = .67). Central nervous system anomalies and echogenic liver loci were significantly more common among fetuses with positive amniotic fluid polymerase chain reaction results for adenovirus (P

Original languageEnglish (US)
Pages (from-to)758-763
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume189
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

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Adenoviridae
Fetus
Amniotic Fluid
Nervous System Malformations
Abnormal Karyotype
Amniocentesis
Multiplex Polymerase Chain Reaction
Second Pregnancy Trimester
Human Genome
Pregnancy Outcome
Observational Studies
Central Nervous System
Prospective Studies
Viruses
Pregnancy
Polymerase Chain Reaction
Liver
Genes

Keywords

  • Adenovirus
  • Amniotic fluid
  • Fetal infection
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Baschat, A., Towbin, J., Bowles, N. E., Harman, C. R., & Weiner, C. P. (2003). Is adenovirus a fetal pathogen? American Journal of Obstetrics and Gynecology, 189(3), 758-763. https://doi.org/10.1067/S0002-9378(03)00720-8

Is adenovirus a fetal pathogen? / Baschat, Ahmet; Towbin, Jeffrey; Bowles, Neil E.; Harman, Christopher R.; Weiner, Carl P.

In: American Journal of Obstetrics and Gynecology, Vol. 189, No. 3, 01.09.2003, p. 758-763.

Research output: Contribution to journalArticle

Baschat, A, Towbin, J, Bowles, NE, Harman, CR & Weiner, CP 2003, 'Is adenovirus a fetal pathogen?', American Journal of Obstetrics and Gynecology, vol. 189, no. 3, pp. 758-763. https://doi.org/10.1067/S0002-9378(03)00720-8
Baschat, Ahmet ; Towbin, Jeffrey ; Bowles, Neil E. ; Harman, Christopher R. ; Weiner, Carl P. / Is adenovirus a fetal pathogen?. In: American Journal of Obstetrics and Gynecology. 2003 ; Vol. 189, No. 3. pp. 758-763.
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