Ironing out tau's role in parkinsonism

Jeannette N. Stankowski; Valina L. Dawson; Ted M. Dawson

doi:10.1038/nm.2668

Ironing out tau's role in parkinsonism

Jeannette N. Stankowski, Valina L. Dawson, Ted M. Dawson

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291-295).

Original language	English (US)
Pages (from-to)	197-198
Number of pages	2
Journal	Nature medicine
Volume	18
Issue number	2
DOIs	https://doi.org/10.1038/nm.2668
State	Published - Feb 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Ironing out tau's role in parkinsonism",

abstract = "A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291-295).",

author = "Stankowski, {Jeannette N.} and Dawson, {Valina L.} and Dawson, {Ted M.}",

year = "2012",

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pages = "197--198",

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T1 - Ironing out tau's role in parkinsonism

AU - Stankowski, Jeannette N.

AU - Dawson, Valina L.

AU - Dawson, Ted M.

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N2 - A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291-295).

AB - A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291-295).

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VL - 18

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JO - Nature medicine

JF - Nature medicine

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Ironing out tau's role in parkinsonism

Abstract

ASJC Scopus subject areas

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