Ironing out tau's role in parkinsonism

Jeannette N. Stankowski, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalShort surveypeer-review


A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291-295).

Original languageEnglish (US)
Pages (from-to)197-198
Number of pages2
JournalNature medicine
Issue number2
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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