Abstract
Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-100 |
| Number of pages | 8 |
| Journal | Trends in Cell Biology |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Iron uptake and metabolism in the new millennium. / Dunn, Louise L.; Suryo Rahmanto, Yohan; Richardson, Des R.
In: Trends in Cell Biology, Vol. 17, No. 2, 01.02.2007, p. 93-100.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Iron uptake and metabolism in the new millennium
AU - Dunn, Louise L.
AU - Suryo Rahmanto, Yohan
AU - Richardson, Des R.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.
AB - Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.
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UR - http://www.scopus.com/inward/citedby.url?scp=33846691564&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2006.12.003
DO - 10.1016/j.tcb.2006.12.003
M3 - Review article
C2 - 17194590
AN - SCOPUS:33846691564
VL - 17
SP - 93
EP - 100
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 2
ER -