Iron uptake and metabolism in the new millennium

Louise L. Dunn, Yohan Suryo Rahmanto, Des R. Richardson

Research output: Contribution to journalReview article

Abstract

Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalTrends in Cell Biology
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

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Iron
Transferrin
Hepcidins
Hemeproteins
Transferrin Receptors
Carrier Proteins
Homeostasis
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Dunn, L. L., Suryo Rahmanto, Y., & Richardson, D. R. (2007). Iron uptake and metabolism in the new millennium. Trends in Cell Biology, 17(2), 93-100. https://doi.org/10.1016/j.tcb.2006.12.003

Iron uptake and metabolism in the new millennium. / Dunn, Louise L.; Suryo Rahmanto, Yohan; Richardson, Des R.

In: Trends in Cell Biology, Vol. 17, No. 2, 01.02.2007, p. 93-100.

Research output: Contribution to journalReview article

Dunn, LL, Suryo Rahmanto, Y & Richardson, DR 2007, 'Iron uptake and metabolism in the new millennium', Trends in Cell Biology, vol. 17, no. 2, pp. 93-100. https://doi.org/10.1016/j.tcb.2006.12.003
Dunn, Louise L. ; Suryo Rahmanto, Yohan ; Richardson, Des R. / Iron uptake and metabolism in the new millennium. In: Trends in Cell Biology. 2007 ; Vol. 17, No. 2. pp. 93-100.
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