TY - JOUR
T1 - Iron uptake and metabolism in the new millennium
AU - Dunn, Louise L.
AU - Rahmanto, Yohan Suryo
AU - Richardson, Des R.
N1 - Funding Information:
D.R.R. thanks the National Health and Medical Research Council, Australian Research Council and Muscular Dystrophy Association USA for project grant and fellowship support. L.L.D. and Y.S.R. were supported by NHMRC and University of Sydney Postgraduate Scholarships, respectively. We thank David Lovejoy, Robert Sutak, Danuta Kalinowski and Megan Whitnall of the Iron Metabolism and Chelation Program for their comments on the article before submission.
PY - 2007/2
Y1 - 2007/2
N2 - Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.
AB - Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved through iron transport, storage and regulatory proteins. The functions of some of these molecules are well described, for example transferrin and transferrin receptor-1, whereas the roles of others, such as the transferrin homolog melanotransferrin, remain unclear. The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Here, we focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism.
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U2 - 10.1016/j.tcb.2006.12.003
DO - 10.1016/j.tcb.2006.12.003
M3 - Review article
C2 - 17194590
AN - SCOPUS:33846691564
VL - 17
SP - 93
EP - 100
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 2
ER -