Iron supplementation during human immunodeficiency virus infection: A double-edged sword?

T. D. Clark, Richard David Semba

Research output: Contribution to journalArticle

Abstract

Although iron supplementation is considered beneficial for groups at risk for anemia, concern has been raised that it could be harmful during human immunodeficiency virus (HIV) infection. Studies suggest: (1) faster HIV disease progression in thalassemia major patients receiving inadequate doses of iron-chelating drug; (2) higher mortality among patients receiving iron supplementation with dapsone compared with aerosolized pentamidine for prophylaxis against Pneumocytis carinii pneumonia; (3) higher iron stores and mortality among patients with haptoglobin Hp 2-2 phenotype; and (4) shorter survival among patients with high bone marrow iron deposition. These studies largely involved men in developed countries. Among HIV-infected pregnant women in Africa with a high prevalence of iron deficiency, no relationship was found between indicators of iron status and HIV disease severity. The available data do not contraindicate the current practice of iron supplementation in developing countries where there is a high prevalence of both HIV infection and iron deficiency.

Original languageEnglish (US)
Pages (from-to)476-479
Number of pages4
JournalMedical Hypotheses
Volume57
Issue number4
DOIs
StatePublished - 2001

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Virus Diseases
Iron
HIV
Pentamidine
Dapsone
Haptoglobins
Mortality
beta-Thalassemia
Developed Countries
Developing Countries
Disease Progression
Anemia
Pregnant Women
Pneumonia
Bone Marrow
Phenotype
Survival

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Iron supplementation during human immunodeficiency virus infection : A double-edged sword? / Clark, T. D.; Semba, Richard David.

In: Medical Hypotheses, Vol. 57, No. 4, 2001, p. 476-479.

Research output: Contribution to journalArticle

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