Iron status and indicators of human immunodeficiency virus disease severity among pregnant women in Malawi

Richard D. Semba; Taha E. Taha; Newton Kumwenda; Laban Mtimavalye; Robin Broadhead; Paolo G. Miotti; John D. Chiphangwi

doi:10.1086/320167

Iron status and indicators of human immunodeficiency virus disease severity among pregnant women in Malawi

Richard D. Semba, Taha E. Taha, Newton Kumwenda, Laban Mtimavalye, Robin Broadhead, Paolo G. Miotti, John D. Chiphangwi

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24 Scopus citations

Abstract

The relationships among hemoglobin, ferritin, and transferrin receptor levels and 2 markers of human immunodeficiency virus (HIV) disease severity - HIV load and CD4⁺ lymphocyte count - were characterized among 483 pregnant women in Malawi, Africa. The only significant correlation was an inverse correlation between hemoglobin level and plasma HIV load (r = -.104; P < .03). The prevalence of iron deficiency anemia was not significantly different across quartiles of HIV load or CD4⁺ lymphocyte count. In contrast to previous studies, these data suggest that iron status is not related to markers of HIV disease severity in pregnant women in Africa.

Original language	English (US)
Pages (from-to)	1496-1499
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	32
Issue number	10
DOIs	https://doi.org/10.1086/320167
State	Published - May 15 2001

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/320167

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title = "Iron status and indicators of human immunodeficiency virus disease severity among pregnant women in Malawi",

abstract = "The relationships among hemoglobin, ferritin, and transferrin receptor levels and 2 markers of human immunodeficiency virus (HIV) disease severity - HIV load and CD4+ lymphocyte count - were characterized among 483 pregnant women in Malawi, Africa. The only significant correlation was an inverse correlation between hemoglobin level and plasma HIV load (r = -.104; P < .03). The prevalence of iron deficiency anemia was not significantly different across quartiles of HIV load or CD4+ lymphocyte count. In contrast to previous studies, these data suggest that iron status is not related to markers of HIV disease severity in pregnant women in Africa.",

author = "Semba, {Richard D.} and Taha, {Taha E.} and Newton Kumwenda and Laban Mtimavalye and Robin Broadhead and Miotti, {Paolo G.} and Chiphangwi, {John D.}",

note = "Funding Information: Financial support: National Institutes of Health (HD-32247, HD-30042, and HIVNET contract N01-AI-35173-117); Fogarty International Center; United States Agency for International Development (Cooperative Agreement HRN-A-00-97-00015-00).",

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AU - Semba, Richard D.

AU - Taha, Taha E.

AU - Kumwenda, Newton

AU - Mtimavalye, Laban

AU - Broadhead, Robin

AU - Miotti, Paolo G.

AU - Chiphangwi, John D.

N1 - Funding Information: Financial support: National Institutes of Health (HD-32247, HD-30042, and HIVNET contract N01-AI-35173-117); Fogarty International Center; United States Agency for International Development (Cooperative Agreement HRN-A-00-97-00015-00).

PY - 2001/5/15

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N2 - The relationships among hemoglobin, ferritin, and transferrin receptor levels and 2 markers of human immunodeficiency virus (HIV) disease severity - HIV load and CD4+ lymphocyte count - were characterized among 483 pregnant women in Malawi, Africa. The only significant correlation was an inverse correlation between hemoglobin level and plasma HIV load (r = -.104; P < .03). The prevalence of iron deficiency anemia was not significantly different across quartiles of HIV load or CD4+ lymphocyte count. In contrast to previous studies, these data suggest that iron status is not related to markers of HIV disease severity in pregnant women in Africa.

AB - The relationships among hemoglobin, ferritin, and transferrin receptor levels and 2 markers of human immunodeficiency virus (HIV) disease severity - HIV load and CD4+ lymphocyte count - were characterized among 483 pregnant women in Malawi, Africa. The only significant correlation was an inverse correlation between hemoglobin level and plasma HIV load (r = -.104; P < .03). The prevalence of iron deficiency anemia was not significantly different across quartiles of HIV load or CD4+ lymphocyte count. In contrast to previous studies, these data suggest that iron status is not related to markers of HIV disease severity in pregnant women in Africa.

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Iron status and indicators of human immunodeficiency virus disease severity among pregnant women in Malawi

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