Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance

Ryan M. Antiel, Jonathan S. Caudill, Barbara E U Burkhardt, Chad K. Brands, Philip R. Fischer

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: More than 10% of adolescents suffer from severe fatigue and/or orthostatic intolerance. Adult studies show correlations between iron insufficiency and fatigue as well as between hypovitaminosis D and non-specific pain. We sought to determine whether there were correlations between nutritional factors (iron status, and serum vitamin D levels) and chronic ill health. METHODS: We reviewed records of 188 adolescents with symptoms of fatigue and/or orthostatic intolerance and who underwent autonomic reflex screening. RESULTS: Of the 188 patients, 130 patients (69%) had excessive postural tachycardia (PT) with a heart rate (HR) change of ≥30 bpm. 62 patients (47%, n = 131) had iron insufficiency with low iron stores, and 29 patients (22%, n = 131) were iron deficient. HR change did not correlate to ferritin level (P = 0.15). 21 patients (22%, n = 95) had hypovitaminosis D (25-hydroxyvitamin D ≤20 ng/mL). There was a significant association with hypovitaminosis D and orthostatic intolerance (P = 0.024). CONCLUSION: In patients presenting with chronic fatigue and/or orthostatic intolerance, low ferritin levels and hypovitaminosis D are common, especially in patients with PT.

Original languageEnglish (US)
Pages (from-to)609-611
Number of pages3
JournalSouthern Medical Journal
Volume104
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Orthostatic Intolerance
Fatigue
Iron
Ferritins
Tachycardia
Heart Rate
Vitamin D
Reflex
Pain
Health

Keywords

  • adolescents
  • hypovitaminosis D
  • low iron storage
  • orthostatic

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance. / Antiel, Ryan M.; Caudill, Jonathan S.; Burkhardt, Barbara E U; Brands, Chad K.; Fischer, Philip R.

In: Southern Medical Journal, Vol. 104, No. 8, 08.2011, p. 609-611.

Research output: Contribution to journalArticle

Antiel, Ryan M. ; Caudill, Jonathan S. ; Burkhardt, Barbara E U ; Brands, Chad K. ; Fischer, Philip R. / Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance. In: Southern Medical Journal. 2011 ; Vol. 104, No. 8. pp. 609-611.
@article{99e9f74621ee4a8ca034c2753b6d308e,
title = "Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance",
abstract = "OBJECTIVES: More than 10{\%} of adolescents suffer from severe fatigue and/or orthostatic intolerance. Adult studies show correlations between iron insufficiency and fatigue as well as between hypovitaminosis D and non-specific pain. We sought to determine whether there were correlations between nutritional factors (iron status, and serum vitamin D levels) and chronic ill health. METHODS: We reviewed records of 188 adolescents with symptoms of fatigue and/or orthostatic intolerance and who underwent autonomic reflex screening. RESULTS: Of the 188 patients, 130 patients (69{\%}) had excessive postural tachycardia (PT) with a heart rate (HR) change of ≥30 bpm. 62 patients (47{\%}, n = 131) had iron insufficiency with low iron stores, and 29 patients (22{\%}, n = 131) were iron deficient. HR change did not correlate to ferritin level (P = 0.15). 21 patients (22{\%}, n = 95) had hypovitaminosis D (25-hydroxyvitamin D ≤20 ng/mL). There was a significant association with hypovitaminosis D and orthostatic intolerance (P = 0.024). CONCLUSION: In patients presenting with chronic fatigue and/or orthostatic intolerance, low ferritin levels and hypovitaminosis D are common, especially in patients with PT.",
keywords = "adolescents, hypovitaminosis D, low iron storage, orthostatic",
author = "Antiel, {Ryan M.} and Caudill, {Jonathan S.} and Burkhardt, {Barbara E U} and Brands, {Chad K.} and Fischer, {Philip R.}",
year = "2011",
month = "8",
doi = "10.1097/SMJ.0b013e3182246809",
language = "English (US)",
volume = "104",
pages = "609--611",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance

AU - Antiel, Ryan M.

AU - Caudill, Jonathan S.

AU - Burkhardt, Barbara E U

AU - Brands, Chad K.

AU - Fischer, Philip R.

PY - 2011/8

Y1 - 2011/8

N2 - OBJECTIVES: More than 10% of adolescents suffer from severe fatigue and/or orthostatic intolerance. Adult studies show correlations between iron insufficiency and fatigue as well as between hypovitaminosis D and non-specific pain. We sought to determine whether there were correlations between nutritional factors (iron status, and serum vitamin D levels) and chronic ill health. METHODS: We reviewed records of 188 adolescents with symptoms of fatigue and/or orthostatic intolerance and who underwent autonomic reflex screening. RESULTS: Of the 188 patients, 130 patients (69%) had excessive postural tachycardia (PT) with a heart rate (HR) change of ≥30 bpm. 62 patients (47%, n = 131) had iron insufficiency with low iron stores, and 29 patients (22%, n = 131) were iron deficient. HR change did not correlate to ferritin level (P = 0.15). 21 patients (22%, n = 95) had hypovitaminosis D (25-hydroxyvitamin D ≤20 ng/mL). There was a significant association with hypovitaminosis D and orthostatic intolerance (P = 0.024). CONCLUSION: In patients presenting with chronic fatigue and/or orthostatic intolerance, low ferritin levels and hypovitaminosis D are common, especially in patients with PT.

AB - OBJECTIVES: More than 10% of adolescents suffer from severe fatigue and/or orthostatic intolerance. Adult studies show correlations between iron insufficiency and fatigue as well as between hypovitaminosis D and non-specific pain. We sought to determine whether there were correlations between nutritional factors (iron status, and serum vitamin D levels) and chronic ill health. METHODS: We reviewed records of 188 adolescents with symptoms of fatigue and/or orthostatic intolerance and who underwent autonomic reflex screening. RESULTS: Of the 188 patients, 130 patients (69%) had excessive postural tachycardia (PT) with a heart rate (HR) change of ≥30 bpm. 62 patients (47%, n = 131) had iron insufficiency with low iron stores, and 29 patients (22%, n = 131) were iron deficient. HR change did not correlate to ferritin level (P = 0.15). 21 patients (22%, n = 95) had hypovitaminosis D (25-hydroxyvitamin D ≤20 ng/mL). There was a significant association with hypovitaminosis D and orthostatic intolerance (P = 0.024). CONCLUSION: In patients presenting with chronic fatigue and/or orthostatic intolerance, low ferritin levels and hypovitaminosis D are common, especially in patients with PT.

KW - adolescents

KW - hypovitaminosis D

KW - low iron storage

KW - orthostatic

UR - http://www.scopus.com/inward/record.url?scp=80051480286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051480286&partnerID=8YFLogxK

U2 - 10.1097/SMJ.0b013e3182246809

DO - 10.1097/SMJ.0b013e3182246809

M3 - Article

VL - 104

SP - 609

EP - 611

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 8

ER -