Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008

Yangho Kim, Byung Kook Lee

Research output: Contribution to journalArticle

Abstract

Introduction: We present data from Korean National Health and Nutritional Examination Survey (KNHANES) 2008 on the distribution of blood manganese (Mn) levels and their associations with iron deficiency in a representative sample of the adult Korean population. Methods: This study was based on data obtained in KNHANES 2008, which was conducted for three years (2007-2009) using a rolling sampling design that involves a complex, stratified, multistage, probability-cluster survey of a representative sample of the noninstitutionalized civilian population in South Korea. Results: Geometric means (GMs) of blood Mn in the low serum ferritin group in women, men, and all participants were significantly higher than in the normal group. GMs of blood Mn in the low-normal serum ferritin groups in women and all participants were significantly higher than in the normal group. In addition, multiple regression analysis after controlling for covariates including gender, age, regional area, education level, and smoking and drinking status showed that blood Mn was significantly higher in the low ferritin group in women, men, and all participants compared with the normal group, whereas blood Mn was significantly higher in the low-normal ferritin group only in women and all participants. Discussion: The present study shows that iron deficiency increases blood Mn level in the general population. To the best of our knowledge, the present study is the first to show an association between blood Mn level and ferritin level in a representative sample of the adult population such as that evaluated in KNHANES.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalNeuroToxicology
Volume32
Issue number2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Nutrition Surveys
Manganese
Blood
Iron
Ferritins
Health
Population
Republic of Korea
Blood Group Antigens
Serum
Regression analysis
Drinking
Education
Smoking
Regression Analysis
Sampling

Keywords

  • Anemia
  • Ferritin
  • Iron deficiency
  • Manganese

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008. / Kim, Yangho; Lee, Byung Kook.

In: NeuroToxicology, Vol. 32, No. 2, 03.2011, p. 247-254.

Research output: Contribution to journalArticle

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