Anemia ferropriva diminui hemólise em anemia falciforme

Translated title of the contribution: Iron deficiency decreases hemolysis in sickle cell anemia

Oswaldo Castro, Adriana Medina, Peter Gaskin, Gregory J. Kato, Victor R. Gordeuk

Research output: Contribution to journalArticle

Abstract

A woman with homozygous sickle cell disease developed severe iron deficiency due to long-standing uterine bleeding. At this point, the serum lactic dehydrogenase level was normal and the reticulocyte count was only minimally elevated. This suggested that the low red cell hemoglobin concentration that resulted from iron deficiency also decreased Hb S polymerization and lowered the hemolytic rate. Iron replacement led first to a substantially improved hemoglobin concentration with only a minimal increase in the hemolytic rate and secondarily to a modest further improvement in the hemoglobin concentration and a marked increase in the hemolytic rate. The hematologic changes observed in this patient, and those in other iron deficient sickle cell patients reported in the literature, suggest that it may be appropriate to consider the induction of an intermediate iron deficient stage as experimental treatment in adult sickle cell patients.

Translated title of the contributionIron deficiency decreases hemolysis in sickle cell anemia
Original languagePortuguese
Pages (from-to)51-53
Number of pages3
JournalRevista Brasileira de Hematologia e Hemoterapia
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Hemolysis
  • Iron deficiency
  • Sickle cell anemia

ASJC Scopus subject areas

  • Hematology

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