Iron-deficiency anaemia enhances red blood cell oxidative stress

Nagababu Enika, Seema Gulyani, Christopher J Earley, Roy Cutler, Mark Mattson, Joseph Rifkind

Research output: Contribution to journalArticle

Abstract

Oxidative stress associated with iron deficiency anaemia in a murine model was studied feeding an iron-deficient diet. Anaemia was monitored by a decrease in hematocrit and haemoglobin. For the 9 week study an increase in total iron binding capacity was also demonstrated. Anaemia resulted in an increase in red blood cells (RBC) oxidative stress as indicated by increased levels of fluorescent heme degradation products (1.24-fold after 5 weeks; 2.1-fold after 9 weeks). The increase in oxidative stress was further confirmed by elevated levels of methemoglobin for mice fed an iron-deficient diet. Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia.

Original languageEnglish (US)
Pages (from-to)824-829
Number of pages6
JournalFree Radical Research
Volume42
Issue number9
DOIs
StatePublished - 2008

Fingerprint

Oxidative stress
Iron-Deficiency Anemias
Oxidative Stress
Blood
Iron
Erythrocytes
Cells
Anemia
Hemoglobins
Diet
Methemoglobin
Nutrition
Heme
Hematocrit
Degradation

Keywords

  • Anaemia
  • Fluorescence
  • Heme degradation
  • Oxidative stress
  • Red blood cells

ASJC Scopus subject areas

  • Biochemistry

Cite this

Iron-deficiency anaemia enhances red blood cell oxidative stress. / Enika, Nagababu; Gulyani, Seema; Earley, Christopher J; Cutler, Roy; Mattson, Mark; Rifkind, Joseph.

In: Free Radical Research, Vol. 42, No. 9, 2008, p. 824-829.

Research output: Contribution to journalArticle

Enika, N, Gulyani, S, Earley, CJ, Cutler, R, Mattson, M & Rifkind, J 2008, 'Iron-deficiency anaemia enhances red blood cell oxidative stress', Free Radical Research, vol. 42, no. 9, pp. 824-829. https://doi.org/10.1080/10715760802459879
Enika, Nagababu ; Gulyani, Seema ; Earley, Christopher J ; Cutler, Roy ; Mattson, Mark ; Rifkind, Joseph. / Iron-deficiency anaemia enhances red blood cell oxidative stress. In: Free Radical Research. 2008 ; Vol. 42, No. 9. pp. 824-829.
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