Iron-deficiency anaemia enhances red blood cell oxidative stress

Enika Nagababu, Seema Gulyani, Christopher J. Earley, Roy Cutler, Mark Mattson, Joseph Rifkind

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress associated with iron deficiency anaemia in a murine model was studied feeding an iron-deficient diet. Anaemia was monitored by a decrease in hematocrit and haemoglobin. For the 9 week study an increase in total iron binding capacity was also demonstrated. Anaemia resulted in an increase in red blood cells (RBC) oxidative stress as indicated by increased levels of fluorescent heme degradation products (1.24-fold after 5 weeks; 2.1-fold after 9 weeks). The increase in oxidative stress was further confirmed by elevated levels of methemoglobin for mice fed an iron-deficient diet. Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia.

Original languageEnglish (US)
Pages (from-to)824-829
Number of pages6
JournalFree Radical Research
Volume42
Issue number9
DOIs
StatePublished - 2008

Keywords

  • Anaemia
  • Fluorescence
  • Heme degradation
  • Oxidative stress
  • Red blood cells

ASJC Scopus subject areas

  • Biochemistry

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