Iron chelation as a chemotherapeutic strategy for falciparum malaria

V. R. Gordeuk, Philip E Thuma, G. M. Brittenham, G. Biemba, S. Zulu, G. Simwanza, P. Kalense, A. M'Hango, D. Parry, A. A. Poltera, M. Aikawa

Research output: Contribution to journalArticle

Abstract

To examine the effect of iron chelation against human malaria, 37 Zambians with asymptomatic Plasmodium falciparum infections were randomly assigned to 72-hr infusions of desferrioxamine B or placebo. Mean concentrations of ring forms decreased significantly with desferrioxamine B (P < 0.001) but not with a placebo. Over seven days of observation, mean parasite concentrations remained at the initial levels in six individuals originally given placebo, but decreased promptly with administration of desferrioxamine B (P = 0.001). Mean parasitemia was significantly lower for up to four weeks in 16 subjects treated with desferrioxamine B when compared with the eight who had received placebo only (P = 0.027). We conclude that iron chelation has antiplasmodial activity and may offer a new therapeutic strategy for falciparum malaria.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume48
Issue number2
StatePublished - 1993
Externally publishedYes

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Deferoxamine
Falciparum Malaria
Iron
Placebos
Malaria
Parasitemia
Plasmodium falciparum
Parasites
Observation
Therapeutics

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)
  • Virology
  • Infectious Diseases

Cite this

Gordeuk, V. R., Thuma, P. E., Brittenham, G. M., Biemba, G., Zulu, S., Simwanza, G., ... Aikawa, M. (1993). Iron chelation as a chemotherapeutic strategy for falciparum malaria. American Journal of Tropical Medicine and Hygiene, 48(2), 193-197.

Iron chelation as a chemotherapeutic strategy for falciparum malaria. / Gordeuk, V. R.; Thuma, Philip E; Brittenham, G. M.; Biemba, G.; Zulu, S.; Simwanza, G.; Kalense, P.; M'Hango, A.; Parry, D.; Poltera, A. A.; Aikawa, M.

In: American Journal of Tropical Medicine and Hygiene, Vol. 48, No. 2, 1993, p. 193-197.

Research output: Contribution to journalArticle

Gordeuk, VR, Thuma, PE, Brittenham, GM, Biemba, G, Zulu, S, Simwanza, G, Kalense, P, M'Hango, A, Parry, D, Poltera, AA & Aikawa, M 1993, 'Iron chelation as a chemotherapeutic strategy for falciparum malaria', American Journal of Tropical Medicine and Hygiene, vol. 48, no. 2, pp. 193-197.
Gordeuk VR, Thuma PE, Brittenham GM, Biemba G, Zulu S, Simwanza G et al. Iron chelation as a chemotherapeutic strategy for falciparum malaria. American Journal of Tropical Medicine and Hygiene. 1993;48(2):193-197.
Gordeuk, V. R. ; Thuma, Philip E ; Brittenham, G. M. ; Biemba, G. ; Zulu, S. ; Simwanza, G. ; Kalense, P. ; M'Hango, A. ; Parry, D. ; Poltera, A. A. ; Aikawa, M. / Iron chelation as a chemotherapeutic strategy for falciparum malaria. In: American Journal of Tropical Medicine and Hygiene. 1993 ; Vol. 48, No. 2. pp. 193-197.
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