Iron-biofortified rice improves the iron stores of nonanemic filipino women

Jere D. Haas, John L. Beard, Laura E. Murray-Kolb, Angelita M. Del Mundo, Angelina Felix, Glenn B. Gregorio

Research output: Contribution to journalArticle

Abstract

Iron deficiency is endemic in much of the world, and food system-based approaches to eradication may be viable with new plant breeding approaches to increase the micronutrient content in staple crops. It is thought that conventional plant breeding approaches provide varieties of rice that have 400-500% higher iron contents than varieties commonly consumed in much of Asia. The efficacy of consuming high-iron rice was tested during a 9-mo feeding trial with a double-blind dietary intervention in 192 religious sisters living in 10 convents around metro Manila, the Philippines. Subjects were randomly assigned to consume either high-iron rice (3.21 mg/kg Fe) or a local variety of control rice (0.57 mg/kg Fe), and daily food consumption was monitored. The high-iron rice contributed 1.79 mg Fe/d to the diet in contrast to 0.37 mg Fe/d from the control rice. The 17% difference in total dietary iron consumption compared with controls (10.16 ± 1.06 vs. 8.44 ± 1.82 mg/d) resulted in a modest increase in serum ferritin (P = 0.10) and total body iron (P = 0.06) and no increase in hemoglobin (P = 0.59). However, the response was greater in nonanemic subjects for ferritin (P = 0.02) and body iron (P = 0.05), representing a 20% increase after controlling for baseline values and daily rice consumption. The greatest improvements in iron status were seen in those nonanemic women who had the lowest baseline iron status and in those who consumed the most iron from rice. Consumption of biofortified rice, without any other changes in diet, is efficacious in improving iron stores of women with iron-poor diets in the developing world.

Original languageEnglish (US)
Pages (from-to)2823-2830
Number of pages8
JournalJournal of Nutrition
Volume135
Issue number12
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Filipinos
Iron
iron
rice
Ferritins
Diet
ferritin
plant breeding
Oryza
Dietary Iron
diet
Food
Philippines
Micronutrients
staples
dietary minerals
food consumption

Keywords

  • Biofortification
  • Ferritin
  • Iron
  • Philippines
  • Rice

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Haas, J. D., Beard, J. L., Murray-Kolb, L. E., Del Mundo, A. M., Felix, A., & Gregorio, G. B. (2005). Iron-biofortified rice improves the iron stores of nonanemic filipino women. Journal of Nutrition, 135(12), 2823-2830.

Iron-biofortified rice improves the iron stores of nonanemic filipino women. / Haas, Jere D.; Beard, John L.; Murray-Kolb, Laura E.; Del Mundo, Angelita M.; Felix, Angelina; Gregorio, Glenn B.

In: Journal of Nutrition, Vol. 135, No. 12, 12.2005, p. 2823-2830.

Research output: Contribution to journalArticle

Haas, JD, Beard, JL, Murray-Kolb, LE, Del Mundo, AM, Felix, A & Gregorio, GB 2005, 'Iron-biofortified rice improves the iron stores of nonanemic filipino women', Journal of Nutrition, vol. 135, no. 12, pp. 2823-2830.
Haas JD, Beard JL, Murray-Kolb LE, Del Mundo AM, Felix A, Gregorio GB. Iron-biofortified rice improves the iron stores of nonanemic filipino women. Journal of Nutrition. 2005 Dec;135(12):2823-2830.
Haas, Jere D. ; Beard, John L. ; Murray-Kolb, Laura E. ; Del Mundo, Angelita M. ; Felix, Angelina ; Gregorio, Glenn B. / Iron-biofortified rice improves the iron stores of nonanemic filipino women. In: Journal of Nutrition. 2005 ; Vol. 135, No. 12. pp. 2823-2830.
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