Iron and noncontrast magnetic resonance T2∗as a marker of intraplaque iron in human atherosclerosis

Marshall W. Winner, Travis Sharkey-Toppen, Xiaolan Zhang, Michael L. Pennell, Orlando P. Simonetti, Jay L. Zweier, Patrick S. Vaccaro, Subha V. Raman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Iron has been implicated in atherogenesis and plaque destabilization, whereas less is known about iron-related proteins in this disease. We compared ex vivo quantities with in vivo vessel wall T2∗, which is a noncontrast magnetic resonance relaxation time that quantitatively shortens with increased tissue iron content. We also tested the hypothesis that patients with carotid atherosclerosis have abnormal T2∗times vs controls that would help support a role for iron in human atherosclerosis. Methods Forty-six patients undergoing carotid endarterectomy and 14 subjects without carotid disease were prospectively enrolled to undergo carotid magnetic resonance imaging. Ex vivo measurements were performed on explanted plaque and 17 mammary artery samples. Results Plaques vs normal arteries had higher levels of ferritin (median, 7.3 [interquartile range (IQR), 4-13.8] vs 1.0 [IQR, 0.6-1.3] ng/mg; P

Original languageEnglish (US)
Pages (from-to)1556-1564
Number of pages9
JournalJournal of Vascular Surgery
Volume61
Issue number6
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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