Iron and deferoxamine in lymphocyte blastogenesis

J. J. Lipsky, P. S. Lietman

Research output: Contribution to journalArticlepeer-review

Abstract

Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalJournal of Immunopharmacology
Volume2
Issue number2
StatePublished - 1980

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology

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