Iron and deferoxamine in lymphocyte blastogenesis

J. J. Lipsky, P. S. Lietman

Research output: Contribution to journalArticle

Abstract

Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalJournal of Immunopharmacology
Volume2
Issue number2
StatePublished - 1980

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Deferoxamine
Lymphocytes
Lymphocyte Activation
Iron
Iron-Deficiency Anemias
Chelating Agents
Tissue culture
Inhibitory Concentration 50
DNA

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology

Cite this

Lipsky, J. J., & Lietman, P. S. (1980). Iron and deferoxamine in lymphocyte blastogenesis. Journal of Immunopharmacology, 2(2), 179-187.

Iron and deferoxamine in lymphocyte blastogenesis. / Lipsky, J. J.; Lietman, P. S.

In: Journal of Immunopharmacology, Vol. 2, No. 2, 1980, p. 179-187.

Research output: Contribution to journalArticle

Lipsky, JJ & Lietman, PS 1980, 'Iron and deferoxamine in lymphocyte blastogenesis', Journal of Immunopharmacology, vol. 2, no. 2, pp. 179-187.
Lipsky, J. J. ; Lietman, P. S. / Iron and deferoxamine in lymphocyte blastogenesis. In: Journal of Immunopharmacology. 1980 ; Vol. 2, No. 2. pp. 179-187.
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