Iron and deferoxamine in lymphocyte blastogenesis

James J. Lipsky; Paul S. Lietman

doi:10.3109/08923978009026396

Iron and deferoxamine in lymphocyte blastogenesis

James J. Lipsky, Paul S. Lietman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Murine lymphocytes in tissue culture accumulate ⁵⁹Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

Original language	English (US)
Pages (from-to)	179-187
Number of pages	9
Journal	Immunopharmacology and Immunotoxicology
Volume	2
Issue number	2
DOIs	https://doi.org/10.3109/08923978009026396
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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10.3109/08923978009026396

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@article{a2f95e932e494fefb97a1e83edcdd62b,

title = "Iron and deferoxamine in lymphocyte blastogenesis",

abstract = "Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.",

author = "Lipsky, {James J.} and Lietman, {Paul S.}",

year = "1980",

doi = "10.3109/08923978009026396",

language = "English (US)",

volume = "2",

pages = "179--187",

journal = "Immunopharmacology and Immunotoxicology",

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publisher = "Informa Healthcare",

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T1 - Iron and deferoxamine in lymphocyte blastogenesis

AU - Lipsky, James J.

AU - Lietman, Paul S.

PY - 1980

Y1 - 1980

N2 - Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

AB - Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

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U2 - 10.3109/08923978009026396

DO - 10.3109/08923978009026396

M3 - Article

AN - SCOPUS:84907114906

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EP - 187

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 2

ER -

Iron and deferoxamine in lymphocyte blastogenesis

Abstract

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