Iron and deferoxamine in lymphocyte blastogenesis

James J. Lipsky, Paul S. Lietman

Research output: Contribution to journalArticle

Abstract

Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume2
Issue number2
DOIs
StatePublished - 1980

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Deferoxamine
Lymphocytes
Lymphocyte Activation
Iron
Iron-Deficiency Anemias
Chelating Agents
Tissue culture
Inhibitory Concentration 50
DNA

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

Cite this

Iron and deferoxamine in lymphocyte blastogenesis. / Lipsky, James J.; Lietman, Paul S.

In: Immunopharmacology and Immunotoxicology, Vol. 2, No. 2, 1980, p. 179-187.

Research output: Contribution to journalArticle

Lipsky, James J. ; Lietman, Paul S. / Iron and deferoxamine in lymphocyte blastogenesis. In: Immunopharmacology and Immunotoxicology. 1980 ; Vol. 2, No. 2. pp. 179-187.
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