IP3 receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Adil A. Khan; Joseph P. Steiner; Michael G. Klein; Martin F. Schneider; Solomon H. Snyder

doi:10.1126/science.1323146

IP₃ receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Adil A. Khan, Joseph P. Steiner, Michael G. Klein, Martin F. Schneider, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca²⁺) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca²⁺-releasing messenger inositol 1,4,5-trisphosphate (IP₃) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP₃ receptors. The IP₃ receptor on T cells appears to be responsible for the entry of Ca²⁺ that initiates proliferative responses.

Original language	English (US)
Pages (from-to)	815-818
Number of pages	4
Journal	Science
Volume	257
Issue number	5071
DOIs	https://doi.org/10.1126/science.1323146
State	Published - 1992

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1323146

Cite this

@article{1e534e24e0e0453fbe6faec0566d7a9d,

title = "IP3 receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor",

abstract = "Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.",

author = "Khan, {Adil A.} and Steiner, {Joseph P.} and Klein, {Michael G.} and Schneider, {Martin F.} and Snyder, {Solomon H.}",

year = "1992",

doi = "10.1126/science.1323146",

language = "English (US)",

volume = "257",

pages = "815--818",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5071",

}

TY - JOUR

T1 - IP3 receptor

T2 - Localization to plasma membrane of T cells and cocapping with the T cell receptor

AU - Khan, Adil A.

AU - Steiner, Joseph P.

AU - Klein, Michael G.

AU - Schneider, Martin F.

AU - Snyder, Solomon H.

PY - 1992

Y1 - 1992

N2 - Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.

AB - Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.

UR - http://www.scopus.com/inward/record.url?scp=0026612898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026612898&partnerID=8YFLogxK

U2 - 10.1126/science.1323146

DO - 10.1126/science.1323146

M3 - Article

C2 - 1323146

AN - SCOPUS:0026612898

VL - 257

SP - 815

EP - 818

JO - Science

JF - Science

SN - 0036-8075

IS - 5071

ER -

IP₃ receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this