Abstract
Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.
Original language | English (US) |
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Pages (from-to) | 815-818 |
Number of pages | 4 |
Journal | Science |
Volume | 257 |
Issue number | 5071 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- General