IP3 receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Adil A. Khan; Joseph P. Steiner; Michael G. Klein; Martin F. Schneider; Solomon H. Snyder

doi:10.1126/science.1323146

IP₃ receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Adil A. Khan, Joseph P. Steiner, Michael G. Klein, Martin F. Schneider, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca²⁺) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca²⁺-releasing messenger inositol 1,4,5-trisphosphate (IP₃) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP₃ receptors. The IP₃ receptor on T cells appears to be responsible for the entry of Ca²⁺ that initiates proliferative responses.

Original language	English (US)
Pages (from-to)	815-818
Number of pages	4
Journal	Science
Volume	257
Issue number	5071
DOIs	https://doi.org/10.1126/science.1323146
State	Published - 1992

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abstract = "Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.",

author = "Khan, {Adil A.} and Steiner, {Joseph P.} and Klein, {Michael G.} and Schneider, {Martin F.} and Snyder, {Solomon H.}",

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AU - Khan, Adil A.

AU - Steiner, Joseph P.

AU - Klein, Michael G.

AU - Schneider, Martin F.

AU - Snyder, Solomon H.

PY - 1992

Y1 - 1992

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AB - Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.

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IP₃ receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

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