IP3 receptor: Localization to plasma membrane of T cells and cocapping with the T cell receptor

Adil A. Khan, Joseph P. Steiner, Michael G. Klein, Martin F. Schneider, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Immune responses in lymphocytes require cellular ccumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.

Original languageEnglish (US)
Pages (from-to)815-818
Number of pages4
JournalScience
Volume257
Issue number5071
DOIs
StatePublished - 1992

ASJC Scopus subject areas

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