Iopentol in cardioangiography. A randomized double-blind study of iopentol versus iohexol

J. E. Goss, J. A. Brinker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of the present study was to evaluate the safety and efficacy of iopentol 350 mg I/ml (Nycomed AS, Oslo, Norway) compared to iohexol 350 mg I/ml (Nycomed AS, Oslo, Norway), in patients undergoing coronary cineangiography and left ventriculography. Fifty patients were randomly allocated to each group. The groups were comparable regarding demographic data and number and volume of contrast medium injections. There were no significant differences between the two treatment groups regarding effects on hemodynamic, electrocardiographic or clinical laboratory parameters. Adverse reactions related to the contrast media were all of mild intensity, and with nearly equal occurrence in the two groups. There were, however, three serious events which were considered to be disease- of procedure-related. Discomfort associated with injection was slightly less with iopentol than with iohexol (p=0.023). The efficacy of both media was similar, with diagnostic visualization judged to be of good or excellent quality in all patients.

Original languageEnglish (US)
Title of host publicationIopentol
Subtitle of host publicationclinical trials with a new non-ionic contrast medium: proceedings of the Nycomed Scientific Symposium 1989. ICS909
EditorsF. Laerum, B. Kendall, F. Laerum, B. Kendall
PublisherElsevier Science Publishers B.V.
Pages145-148
Number of pages4
ISBN (Print)0444813543
StatePublished - Jul 9 1990
Externally publishedYes
EventThe Nycomed Scientific Symposium 1989 -
Duration: Jun 30 1989Jul 1 1989

Publication series

NameIopentol: clinical trials with a new non-ionic contrast medium: proceedings of the Nycomed Scientific Symposium 1989. ICS909

Other

OtherThe Nycomed Scientific Symposium 1989
Period6/30/897/1/89

ASJC Scopus subject areas

  • Medicine(all)

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