Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles

Anil Kumar, Manoj Kumar Muthyala, Sunita Choudhary, Rakesh K. Tiwari, Keykavous Parang

Research output: Contribution to journalArticlepeer-review

Abstract

A convenient synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles was achieved using an ionic liquid as a novel soluble support. Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a number of ketones to afford the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in the presence of thionyl chloride. The reaction of ionic liquid-supported hydrazones with selenium dioxide in acetonitrile afforded 1,2,3-selenadiazoles. The advantages of this methodology were the ease of workup, simple reaction conditions, and high purity.

Original languageEnglish (US)
Pages (from-to)9391-9396
Number of pages6
JournalJournal of Organic Chemistry
Volume77
Issue number20
DOIs
StatePublished - Oct 19 2012
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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