Ionic iodinated contrast medium and amobarbital sodium mixtures: Potential for precipitation

Lee H. Monsein, Timothy J. Miller, Steven K. Kuwahara, Samuel Sostre, Gerald M. Debrun

Research output: Contribution to journalArticle

Abstract

When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalRadiology
Volume184
Issue number2
Publication statusPublished - Aug 1992

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Keywords

  • Arteriovenous malformations, cerebral, 17.75
  • Contrast media, complications
  • Seizures, 134.89

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Monsein, L. H., Miller, T. J., Kuwahara, S. K., Sostre, S., & Debrun, G. M. (1992). Ionic iodinated contrast medium and amobarbital sodium mixtures: Potential for precipitation. Radiology, 184(2), 385-387.