Ionic current correlations are ubiquitous across phyla

Trinh Tran, Cagri T. Unal, Daniel Severin, Laszlo Zaborszky, Horacio G. Rotstein, Alfredo Kirkwood, Jorge Golowasch

Research output: Contribution to journalArticle

Abstract

Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time their magnitudes are correlated. These conductance amplitude correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Although such ionic conductance correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells (GCs) and cholinergic basal forebrain neurons, that the correlation of ionic conductance amplitudes between different ionic currents also exists in vertebrates, and we argue that it is a ubiquitous phenomenon expressed by many species across phyla. We further demonstrate that in dentate gyrus GCs these conductance correlations are likely regulated in a circadian manner. This is reminiscent of the known conductance regulation by neuromodulators in crustaceans. However, in GCs we observe a more nuanced regulation, where for some conductance pairs the correlations are completely eliminated while for others the correlation is quantitatively modified but not obliterated.

Original languageEnglish (US)
Article number1687
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Invertebrates
Vertebrates
Neurons
Dentate Gyrus
Ion Channels
Cholinergic Agents
Neurotransmitter Agents
Homeostasis
Population
Basal Forebrain

ASJC Scopus subject areas

  • General

Cite this

Tran, T., Unal, C. T., Severin, D., Zaborszky, L., Rotstein, H. G., Kirkwood, A., & Golowasch, J. (2019). Ionic current correlations are ubiquitous across phyla. Scientific reports, 9(1), [1687]. https://doi.org/10.1038/s41598-018-38405-6

Ionic current correlations are ubiquitous across phyla. / Tran, Trinh; Unal, Cagri T.; Severin, Daniel; Zaborszky, Laszlo; Rotstein, Horacio G.; Kirkwood, Alfredo; Golowasch, Jorge.

In: Scientific reports, Vol. 9, No. 1, 1687, 01.12.2019.

Research output: Contribution to journalArticle

Tran, T, Unal, CT, Severin, D, Zaborszky, L, Rotstein, HG, Kirkwood, A & Golowasch, J 2019, 'Ionic current correlations are ubiquitous across phyla', Scientific reports, vol. 9, no. 1, 1687. https://doi.org/10.1038/s41598-018-38405-6
Tran T, Unal CT, Severin D, Zaborszky L, Rotstein HG, Kirkwood A et al. Ionic current correlations are ubiquitous across phyla. Scientific reports. 2019 Dec 1;9(1). 1687. https://doi.org/10.1038/s41598-018-38405-6
Tran, Trinh ; Unal, Cagri T. ; Severin, Daniel ; Zaborszky, Laszlo ; Rotstein, Horacio G. ; Kirkwood, Alfredo ; Golowasch, Jorge. / Ionic current correlations are ubiquitous across phyla. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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