Abstract
The sorting and regulation of the Na,K and H,K-ATPases requires that the pump proteins must associate, at least transiently, with kinases, phosphatases, scaffolding molecules, and components of the cellular trafficking maehinery. The identities of these interacting proteins and the nature of their associations with the pump polypeptides have yet to be elucidated. We have begun a series of yeast two-hybrid screens employing structurally defined segments of pump polypeptides as baits in order to gain insight into the nature and function of these interacting proteins.
Original language | English (US) |
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Pages (from-to) | 360-368 |
Number of pages | 9 |
Journal | Annals of the New York Academy of Sciences |
Volume | 986 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Keywords
- Interactions
- Ion pumps
- Polyeystin
- Tetraspan
- Two hybrid
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- History and Philosophy of Science