Ion pump-interacting proteins: Promising new partners

Philipp Pagel, Alessandra Zatti, Tohru Kimura, Amy Duffield, Veronique Chauvet, Vanathy Rajendran, Michael J. Caplan

Research output: Contribution to journalArticle

Abstract

The sorting and regulation of the Na,K and H,K-ATPases requires that the pump proteins must associate, at least transiently, with kinases, phosphatases, scaffolding molecules, and components of the cellular trafficking maehinery. The identities of these interacting proteins and the nature of their associations with the pump polypeptides have yet to be elucidated. We have begun a series of yeast two-hybrid screens employing structurally defined segments of pump polypeptides as baits in order to gain insight into the nature and function of these interacting proteins.

Original languageEnglish (US)
Pages (from-to)360-368
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume986
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Interactions
  • Ion pumps
  • Polyeystin
  • Tetraspan
  • Two hybrid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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