Ion-channel assay technologies: Quo vadis?

Jia Xu; Xiaobo Wang; Brooks Ensign; Min Li; Lei Wu; Antonio Guia; Junquan Xu

doi:10.1016/S1359-6446(01)02095-5

Ion-channel assay technologies: Quo vadis?

Jia Xu, Xiaobo Wang, Brooks Ensign, Min Li, Lei Wu, Antonio Guia, Junquan Xu

School of Medicine

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Although many existing methods are used to study the functions of ion channels and to screen lead compounds for important ion-channel targets, new technologies are being developed for improved performance. It is important to identify the advantages and disadvantages of each technology. In this review, we segment the ion-channel assay market according to distinguishable applications, and compare the needs of each market segment with the capabilities of different technologies in terms of multiple assay attributes. We further discuss the future directions in the development of ion-channel assays.

Original language	English (US)
Pages (from-to)	1278-1287
Number of pages	10
Journal	Drug Discovery Today
Volume	6
Issue number	24
DOIs	https://doi.org/10.1016/S1359-6446(01)02095-5
State	Published - Dec 15 2001

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/S1359-6446(01)02095-5

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title = "Ion-channel assay technologies: Quo vadis?",

abstract = "Although many existing methods are used to study the functions of ion channels and to screen lead compounds for important ion-channel targets, new technologies are being developed for improved performance. It is important to identify the advantages and disadvantages of each technology. In this review, we segment the ion-channel assay market according to distinguishable applications, and compare the needs of each market segment with the capabilities of different technologies in terms of multiple assay attributes. We further discuss the future directions in the development of ion-channel assays.",

author = "Jia Xu and Xiaobo Wang and Brooks Ensign and Min Li and Lei Wu and Antonio Guia and Junquan Xu",

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T2 - Quo vadis?

AU - Xu, Jia

AU - Wang, Xiaobo

AU - Ensign, Brooks

AU - Li, Min

AU - Wu, Lei

AU - Guia, Antonio

AU - Xu, Junquan

PY - 2001/12/15

Y1 - 2001/12/15

N2 - Although many existing methods are used to study the functions of ion channels and to screen lead compounds for important ion-channel targets, new technologies are being developed for improved performance. It is important to identify the advantages and disadvantages of each technology. In this review, we segment the ion-channel assay market according to distinguishable applications, and compare the needs of each market segment with the capabilities of different technologies in terms of multiple assay attributes. We further discuss the future directions in the development of ion-channel assays.

AB - Although many existing methods are used to study the functions of ion channels and to screen lead compounds for important ion-channel targets, new technologies are being developed for improved performance. It is important to identify the advantages and disadvantages of each technology. In this review, we segment the ion-channel assay market according to distinguishable applications, and compare the needs of each market segment with the capabilities of different technologies in terms of multiple assay attributes. We further discuss the future directions in the development of ion-channel assays.

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DO - 10.1016/S1359-6446(01)02095-5

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VL - 6

SP - 1278

EP - 1287

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 24

ER -

Ion-channel assay technologies: Quo vadis?

Abstract

ASJC Scopus subject areas

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