Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases

Chiara Calatozzolo; Emilio Ciusani; Elena Corsini; Francesco Di Meco; Bianca Pollo; Andrea Salmaggi

doi:10.1016/B978-0-12-800896-6.00003-6

Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases

Chiara Calatozzolo, Emilio Ciusani, Elena Corsini, Francesco Di Meco, Bianca Pollo, Andrea Salmaggi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The chemokine-receptor axis CXCL12/CXCR4/CXCR7 is involved in a number of pathophysiological processes, among which migration of tumor cells to distant organs and enhancement of angioneogenesis are indeed relevant in the establishment and growth of metastases. Brain metastases are often associated with a poor prognosis, therefore, the identification of mechanisms involved and of possible therapeutic targets are of paramount importance. CXCL12 is largely expressed in the brain microenvironment where it may act as a chemoattractant for tumor cells displaying positivity for either CXCR4 or CXCR7. In a study on 56 patients operated for brain metastasis at a single institution, expression of CXCL12 at the level of endothelial cells in the brain was predictive of shorter survival at univariate analysis. Despite the CXCL12/CXCR4/CXCR7 system not being uniquely involved in metastasization to the brain, it may be a target for brain metastasis prevention/treatment.

Original language	English (US)
Title of host publication	Brain Metastases from Primary Tumors: Epidemiology, Biology, and Therapy
Publisher	Elsevier Inc.
Pages	25-36
Number of pages	12
ISBN (Print)	9780128008966
DOIs	https://doi.org/10.1016/B978-0-12-800896-6.00003-6
State	Published - Apr 2014
Externally published	Yes

Keywords

Brain metastases
Cell signaling pathways
Chemokine receptor
CXCL12
CXCR4
CXCR7
Metastasization

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-0-12-800896-6.00003-6

Cite this

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title = "Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases",

abstract = "The chemokine-receptor axis CXCL12/CXCR4/CXCR7 is involved in a number of pathophysiological processes, among which migration of tumor cells to distant organs and enhancement of angioneogenesis are indeed relevant in the establishment and growth of metastases. Brain metastases are often associated with a poor prognosis, therefore, the identification of mechanisms involved and of possible therapeutic targets are of paramount importance. CXCL12 is largely expressed in the brain microenvironment where it may act as a chemoattractant for tumor cells displaying positivity for either CXCR4 or CXCR7. In a study on 56 patients operated for brain metastasis at a single institution, expression of CXCL12 at the level of endothelial cells in the brain was predictive of shorter survival at univariate analysis. Despite the CXCL12/CXCR4/CXCR7 system not being uniquely involved in metastasization to the brain, it may be a target for brain metastasis prevention/treatment.",

keywords = "Brain metastases, Cell signaling pathways, Chemokine receptor, CXCL12, CXCR4, CXCR7, Metastasization",

author = "Chiara Calatozzolo and Emilio Ciusani and Elena Corsini and {Di Meco}, Francesco and Bianca Pollo and Andrea Salmaggi",

year = "2014",

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doi = "10.1016/B978-0-12-800896-6.00003-6",

language = "English (US)",

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T1 - Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases

AU - Calatozzolo, Chiara

AU - Ciusani, Emilio

AU - Corsini, Elena

AU - Di Meco, Francesco

AU - Pollo, Bianca

AU - Salmaggi, Andrea

PY - 2014/4

Y1 - 2014/4

N2 - The chemokine-receptor axis CXCL12/CXCR4/CXCR7 is involved in a number of pathophysiological processes, among which migration of tumor cells to distant organs and enhancement of angioneogenesis are indeed relevant in the establishment and growth of metastases. Brain metastases are often associated with a poor prognosis, therefore, the identification of mechanisms involved and of possible therapeutic targets are of paramount importance. CXCL12 is largely expressed in the brain microenvironment where it may act as a chemoattractant for tumor cells displaying positivity for either CXCR4 or CXCR7. In a study on 56 patients operated for brain metastasis at a single institution, expression of CXCL12 at the level of endothelial cells in the brain was predictive of shorter survival at univariate analysis. Despite the CXCL12/CXCR4/CXCR7 system not being uniquely involved in metastasization to the brain, it may be a target for brain metastasis prevention/treatment.

AB - The chemokine-receptor axis CXCL12/CXCR4/CXCR7 is involved in a number of pathophysiological processes, among which migration of tumor cells to distant organs and enhancement of angioneogenesis are indeed relevant in the establishment and growth of metastases. Brain metastases are often associated with a poor prognosis, therefore, the identification of mechanisms involved and of possible therapeutic targets are of paramount importance. CXCL12 is largely expressed in the brain microenvironment where it may act as a chemoattractant for tumor cells displaying positivity for either CXCR4 or CXCR7. In a study on 56 patients operated for brain metastasis at a single institution, expression of CXCL12 at the level of endothelial cells in the brain was predictive of shorter survival at univariate analysis. Despite the CXCL12/CXCR4/CXCR7 system not being uniquely involved in metastasization to the brain, it may be a target for brain metastasis prevention/treatment.

KW - Brain metastases

KW - Cell signaling pathways

KW - Chemokine receptor

KW - CXCL12

KW - CXCR4

KW - CXCR7

KW - Metastasization

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U2 - 10.1016/B978-0-12-800896-6.00003-6

DO - 10.1016/B978-0-12-800896-6.00003-6

M3 - Chapter

AN - SCOPUS:84902414807

SN - 9780128008966

SP - 25

EP - 36

BT - Brain Metastases from Primary Tumors: Epidemiology, Biology, and Therapy

PB - Elsevier Inc.

ER -

Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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