TY - JOUR
T1 - Involvement of nitric oxide system in enhancement of morphine-induced conditioned place preference by agmatine in male mice
AU - Khoshnoodi, Mohammad Ali
AU - Motiei-Langroudi, Rouzbeh
AU - Tahsili-Fahadan, Pouya
AU - Yahyavi-Firouz-Abadi, Noushin
AU - Ghahremani, Mohammad Hossein
AU - Dehpour, Ahmad Reza
PY - 2006/5/22
Y1 - 2006/5/22
N2 - Agmatine recently has been suggested as a neurotransmitter, is able to interact with various effects of morphine like analgesia and dependence. In this study, the effects of agmatine on rewarding properties of morphine, and the possible involvement of nitric oxide (NO) system has been evaluated in an unbiased conditioned place preference (CPP) paradigm. Agmatine (1, 5 and 10 mg/kg, i.p.) alone induced neither CPP nor conditioned place aversion (CPA). Morphine (0.01, 0.05, 0.1 and 0.5 mg/kg, s.c.), while unable to show CPP or CPA, induced CPP in mice pretreated with agmatine. L-arginine (200 mg/kg, i.p.), a NO precursor, significantly enhanced the effect of agmatine (5 mg/kg) on morphine (0.5 mg/kg)-induced place preference. NG-nitro-l-arginine methyl ester (l-NAME; 2.5 mg/kg, i.p.), a non specific nitric oxide synthase (NOS) inhibitor, and aminoguanidine (50 and 100 mg/kg, i.p.), a specific inducible NOS inhibitor, significantly reduced the effect of agmatine (5 mg/kg) on morphine (0.5 mg/kg)-induced place preference. These results suggest the possible involvement of inducible nitric oxide system in potentiating effects of agmatine on morphine-induced place preference.
AB - Agmatine recently has been suggested as a neurotransmitter, is able to interact with various effects of morphine like analgesia and dependence. In this study, the effects of agmatine on rewarding properties of morphine, and the possible involvement of nitric oxide (NO) system has been evaluated in an unbiased conditioned place preference (CPP) paradigm. Agmatine (1, 5 and 10 mg/kg, i.p.) alone induced neither CPP nor conditioned place aversion (CPA). Morphine (0.01, 0.05, 0.1 and 0.5 mg/kg, s.c.), while unable to show CPP or CPA, induced CPP in mice pretreated with agmatine. L-arginine (200 mg/kg, i.p.), a NO precursor, significantly enhanced the effect of agmatine (5 mg/kg) on morphine (0.5 mg/kg)-induced place preference. NG-nitro-l-arginine methyl ester (l-NAME; 2.5 mg/kg, i.p.), a non specific nitric oxide synthase (NOS) inhibitor, and aminoguanidine (50 and 100 mg/kg, i.p.), a specific inducible NOS inhibitor, significantly reduced the effect of agmatine (5 mg/kg) on morphine (0.5 mg/kg)-induced place preference. These results suggest the possible involvement of inducible nitric oxide system in potentiating effects of agmatine on morphine-induced place preference.
KW - Agmatine
KW - Aminoguanidine
KW - Conditioned place preference
KW - Morphine
KW - l-Arginine
KW - l-NAME
UR - http://www.scopus.com/inward/record.url?scp=33646154869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646154869&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2006.01.059
DO - 10.1016/j.neulet.2006.01.059
M3 - Article
C2 - 16490306
AN - SCOPUS:33646154869
SN - 0304-3940
VL - 399
SP - 234
EP - 239
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -