@article{0b12dfb62dbe40108ac44d9fa9b8c1a4,
title = "Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis",
abstract = "IL-18 is induced in food allergy and EoE is food allergen-induced disease. Therefore, we tested the hypothesis whether IL-18 is involved in food allergen-induced EoE pathogenesis. Accordingly, we examined normal SPT + and SPT - EoE patient blood and biopsy samples for IL-18, IL-18Rα, ICAM and VCAM expression. Herein, we show increased IL-18 level is highly significant in food allergen SPT + compared to SPT. - EoE patients. We also report that IL-18Rα + cells and mRNA levels are induced in the esophageal biopsies of EoE patients and blood IL-18 levels correlate with esophageal eosinophilia (P < 0.01). Additionally, we report that the levels of esophageal eosinophil and mast cells correlate with ICAM expression in human EoE. Mechanistically, we show that IL-18 in vitro stimulates iNKT cells and endothelial cells and induce eosinophil active cytokines IL-5 and IL-13. We provide the evidence that IL-18 is critical cytokine involved in activation of iNKT cells and ICAM in promoting human EoE.",
keywords = "EoE, ICAM, IL-18Rα, INKT cells, Interleukin-IL-18",
author = "Rituraj Niranjan and Priya Rajavelu and Ventateshaiah, {Sathisha Upparahalli} and Shukla, {Jai Shankar} and Zaidi, {Asifa K} and Mariswamy, {Siddesha Jalahalli} and Jochen Mattner and Ilana Fortgang and Monika Kowalczyk and Luis Balart and Anshi Shukla and Anil Mishra",
note = "Funding Information: This work was supported in part by the grants NIH RO1 DK067255 , (AM), NIH R01 AI080581 (AM). The authors also thank Drs. Jack Elias, MD. PhD (Yale University) for providing IL-18 transgenic mice, James and Nancy Lee, PhD (Mayo Clinic) for the generous supply of anti-MBP and Marc Rothenberg, MD. PhD, (CCED, Cincinnati Children's, Cincinnati, OH) for the continuous support and encouragement and providing EoE and non-EoE patient samples for the initial study. We also thank the National Institute of Allergy and Infectious Diseases (NIAID) tetramer core facility for providing CD1d-αGalCer-tetramer. We further thank Lee L. Hamm, MD. and Joseph A. Lasky, MD. for providing the facility to continue eosinophil associated disorders research work at Tulane University School of Medicine. Kristen Lingle, RN, Jaya Mishra, PhD and Christine Glynn, RN, research coordinators, for their efforts in IRB approval and enrolling the patients, collecting the samples, recording and providing the patients characteristics. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = apr,
day = "1",
doi = "10.1016/j.clim.2015.01.007",
language = "English (US)",
volume = "157",
pages = "103--113",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",
}