Involvement of IGF-II in human cancer

J. A. Toretsky, Lee J. Helman

Research output: Contribution to journalArticle


IGF-II is a regulatory peptide which appears to be involved significantly in the progression of many tumors, while minimally involved in post-fetal non-tumor tissue. Interruption of IGF-II pathways therefore offers the possibility of tumor control with a high therapeutic index. Investigators should continue to evaluate tumors for the involvement of IGF-II as well as investigate clinically relevant means of disrupting those pathways.

Original languageEnglish (US)
Pages (from-to)367-372
Number of pages6
JournalJournal of Endocrinology
Issue number3
Publication statusPublished - 1996
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology

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